Human T cell epitopes of <em>Mycobacterium tuberculosis</em> are evolutionarily hyperconserved (Publications)
Mycobacterium tuberculosis is an obligate human pathogen capable of persisting in individual hosts for decades. We sequenced the genomes of 21 strains representative of the global diversity and six ma
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents (Publications)
We report herein the synthesis and trypanocidal profile of new (E)-cinnamic N-acylhydrazones (NAHs) designed by exploiting molecular hybridization between the potent cruzain inhibitors (E)-1-(benzo[d]
The <em>in vitro</em> distribution of halofantrine in human blood and <em>Plasmodium falciparum</em>-parasitised red blood cells (Publications)
The in vitro distribution of the antimalarial drug halofantrine was measured in drug-preincubated whole blood after separation of the blood cells from the plasma according to their type. In normal blo
Underestimation of airflow obstruction among young adults using FEV1/FVC <70% as a fixed cut-off: a longitudinal evaluation of clinical and... (Publications)
BACKGROUND: Early detection of airflow obstruction is particularly important among young adults because they are more likely to benefit from intervention. Using the forced expiratory volume in 1 s (FE
Perception of traffic noise emission in Basel City canton in comparison to actually measured noise levels (Publications)
The objective of this study was to assess to what extent the subjective annoyance is influenced by the actually measured or calculated street traffic noise and by sociodemographic factors. In the stud
What defines airflow obstruction in asthma? (Publications)
Asthma guidelines from the Global Initiative for Asthma (GINA) and from the National Heart, Lung, and Blood Institute provide conflicting definitions of airflow obstruction, suggesting a fixed forced
Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS) (Publications)
BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially mod