<em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> infection dynamics: re-infections, recrudescences and relapses (Publications)
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort s
Development of dengue virus serotype-specific NS1 capture assays for the rapid and highly sensitive identification of the infecting serotype in human... (Publications)
Dengue fever can be caused by one of four distinct dengue virus (DENV) serotypes that cocirculate in many parts of the world. Point of care serotype-specific nonstructural protein-1 (NS1) capture assa
Combined approach of backbone amide linking and on-resin n-methylation for the synthesis of bioactive and metabolically stable peptides (Publications)
Rhabdopeptides are a large class of nonribosomal peptides from the bacteria Xenorhabdus and Photorhabdus with low micromolar activity against different protozoa, which are the causative agents of seve
Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold (Publications)
With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate biosynthes
Spectrum of infectious diseases among newly arrived Eritrean refugees in Switzerland: a cross-sectional study (Publications)
OBJECTIVES: Our study aimed at determining the prevalence of selected infectious diseases among recently arrived Eritrean refugees in Switzerland. METHODS: In this cross-sectional study, asymptomatic
Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs (Publications)
Malaria remains a major threat to mankind due to the perpetual emergence of resistance against marketed drugs. Twenty-one pyrazolopyran-based inhibitors bearing terminal biphenyl, aryl sulfonamide, or
Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort (Publications)
BACKGROUND: Microbial exposures in homes of asthmatic adults have been rarely investigated; specificities and implications for respiratory health are not well understood. OBJECTIVE: The objectives of