Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership (Publications)
After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery
Optimizing implementation of preventive chemotherapy against soil-transmitted helminthiasis and intestinal schistosomiasis using high-resolution data:... (Publications)
BACKGROUND: Despite efforts to control neglected tropical diseases (NTDs) using preventive chemotherapy (PC), soil-transmitted helminthiases and schistosomiasis remain widely prevalent in sub-Saharan
Short-, mid-, and long-term epidemiological and economic effects of the World Bank Loan Project on schistosomiasis control in the People's Republic of... (Publications)
It is widely acknowledged that the 10-year World Bank Loan Project (WBLP) on schistosomiasis control in the People's Republic of China played an important role in raising the public and political prof
The Chronic Diseases Clinic of Ifakara (CDCI): establishing a model clinic for chronic care delivery in rural sub-Saharan Africa (Publications)
The rollout of antiretroviral drugs in sub-Saharan Africa to address the huge health impact of the HIV pandemic has been one of the largest projects undertaken in medical history and is an unprecedent
Accelerated development of malaria monoclonal antibodies (Publications)
L9LS, a potent and safe antimalarial monoclonal antibody, demonstrated 88% protective efficacy against infection in a phase 1 trial in healthy adults.(1) These promising results are the first of many
Industrial mining and HIV risk: evidence from 39 mine openings across 16 countries in sub-Saharan Africa (Publications)
OBJECTIVES: The aim of this study was to assess the impact of natural resource extraction projects on HIV transmission risks in local communities in sub-Saharan Africa. DESIGN: Difference-in-differenc
Dolutegravir in real life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral... (Publications)
INTRODUCTION: HIV programmes across many countries in Africa have recently transitioned people living with HIV from efavirenz (EFV)- to dolutegravir (DTG)-containing antiretroviral therapy (ART). As b
Treatment outcome of imported cutaneous leishmaniasis among travellers and migrants infected with<em> Leishmania major</em> and <em>Leishmania... (Publications)
OBJECTIVES: Cutaneous leishmaniasis (CL) in Asia, Northern and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL amon
Parasite viability as a measure of <em>in vivo</em> drug activity in preclinical and early clinical antimalarial drug assessment (Publications)
The rate at which parasitemia declines in a host after treatment with an antimalarial drug is a major metric for assessment of antimalarial drug activity in preclinical models and in early clinical tr
Priority setting in early childhood development: an analytical framework for economic evaluation of interventions (Publications)
BACKGROUND: Early childhood development (ECD) sets the foundation for healthy and successful lives with important ramifications for education, labour market outcomes and other domains of well-being. E