Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies (Publications)
INTRODUCTION: Novel cancer therapies are often approved with evidence from a single pivotal trial alone. There are concerns about the credibility of this evidence. Higher validity may be indicated by
Evolution of subgenomic RNA shapes dengue virus adaptation and epidemiological fitness (Publications)
Changes in dengue virus (DENV) genome affect viral fitness both clinically and epidemiologically. Even in the 3' untranslated region (3' UTR), mutations could affect subgenomic flaviviral RNA (sfRNA)
RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials (Publications)
A malaria vaccine as part of the integrated malaria control and elimination efforts will have a major impact on public health in sub-Sahara Africa. The first malaria vaccine, RTS,S, now enters pilot i
Linking human behaviours and malaria vector biting risk in south-eastern Tanzania (Publications)
To accelerate malaria elimination in areas where core interventions such as insecticide-treated nets (ITNs) are already widely used, it is crucial to consider additional factors associated with persis
Genetic risk scores do not improve asthma prediction in childhood (Publications)
CAPSULE SUMMARY: Genetic risk scores have no added value above familial, perinatal and environmental risk factors in the first year of life to predict childhood asthma.
The feasibility and acceptability of collaborative learning in improving health worker performance on adolescent health: findings from implementation... (Publications)
BACKGROUND: Collaborative learning has been shown to be effective in improving health worker performance, but relatively little is known about the feasibility or acceptability of collaborative learnin
Mortality of neurological disorders in Tanzania: analysis of baseline data from sample vital registration with verbal autopsy (SAVVY) (Publications)
Background: Neurological disorders (ND) have a profound consequence on human productivity, quality of life and survival. There are limited data on the burden of ND in Tanzania due to insufficient cove
The role of socioeconomic status in the association of lung function and air pollution-a pooled analysis of three adult ESCAPE cohorts (Publications)
Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health effects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated