Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis (Publications)
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, c
Variability of reproductive history across the Swiss SAPALDIA cohort - Pattern and main determinants (Publications)
Background: Reproductive characteristics play an aetiological role for many diseases, including reproductive cancers. They have been shown to vary internationally and nationally, but have not yet been
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes (Publications)
BACKGROUND: Air pollutants have been linked to type 2 diabetes (T2D), hypothesized to act through inflammatory pathways and may induce interleukin-6 gene (IL6) in the airway epithelium. The cytokine i
Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a... (Publications)
BACKGROUND: Low concentrations of the anti-inflammatory protein CC16 (approved symbol SCGB1A1) in serum have been associated with accelerated decline in forced expiratory volume in 1 s (FEV1) in patie
Sensitisation to Ambrosia in Switzerland: a public health threat on the wait (Publications)
BACKGROUND: Ambrosia artemisiifolia (short name = Ambrosia common ragweed) pollen is a potent allergen and has recently been found in Switzerland, spreading from the southwest of the country. The aim
Occupational exposure and risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis (Publications)
INTRODUCTION: Due to contradictory literature we have performed a systematic review and meta-analyse of population-based studies that have used Job Exposure Matrices to assess occupational exposure an
Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study (Publications)
A higher incidence of asthma is reported in women compared with men, but evidence in later adulthood is limited. We aimed to determine the 20-year cumulative incidence of adult asthma in Switzerland a
Re-estimated equations for 5th percentiles of lung function variables (Letter to editors) (Publications)
In 1996 we published reference equations for the 5th percentiles of lung function parameters (FVC, FEV1, PEF, FEF25, FEF50, FEF75, FEF25-75, FEV1/FVC) as a function of age and height.1 These reference
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function (Publications)
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 seco