Genome-wide analysis of variations in Plasmodium falciparum parasites population and their impact on different malaria interventions in Tanzania (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/genome-wide-analysis-of-variations-in-plasmodium-falciparum-parasites-population-and-their-impact-on-different-malaria-interventions-in-tanzania
Malaria affects millions of people globally, and the disease remains one of the major public health problems occurring in most parts of the world, causing thousands of deaths each year, especially among
Exploring early sexual differentiation in the malaria parasite Plasmodium falciparum (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/exploring-early-sexual-differentiation-in-the-malaria-parasite-plasmodium-falciparum
Apicomplexa, is the causative agent of the most severe form of malaria in humans. Despite the massive implementation of control interventions, malaria still causes over 200 million clinical cases and half a million [...] million deaths annually. The widespread prevalence of malaria in endemic regions is maintained by a complex yet highly efficient transmission cycle between the human host and mosquito vector. For transmission [...] gametocyte biology will be essential to support the development...
Deciphering Environmental Sensing in Malaria Parasites (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/deciphering-environmental-sensing-in-malaria-parasites
The Malaria Host Interactions Unit (MHIU) is studying the molecular interface between malaria parasites and their human host. Recent findings revealed the existence of intimate links between parasite [...] inducing specific transcriptional responses. This capability is surprising in light of the fact that malaria parasites have lost canonical nutrient sensing pathways present in other eukaryotic organisms. With
Core Malaria Modelling (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....
Towards Elimination of Malaria in Tanzania (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/towards-elimination-of-malaria-in-tanzania
Malaria and poverty entertain a close relationship through historical times. Past studies have abundantly documented the benefits of malaria control on economic development and human well-being, and as [...] of malaria across the country declined, the heterogeneity in transmission greatly increased. At present, some areas in Tanzania remain with a very high transmission and hence with a high malaria burden [...] and risk stratification followed by decentralized malaria control planning has...
Mathematical models to define new malaria immunotherapies and interventions to meet public health needs (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/mathematical-models-to-define-new-malaria-immunotherapies-and-interventions-to-meet-public-health-needs
progress in fighting malaria, there remains a need for new antimalarial interventions to protect children and other vulnerable populations who experience the highest burden of malaria. Developing new in [...] from academia, product development partners, and representatives from malaria-endemic countries. Our focus is on next-generation malaria vaccines, monoclonal antibodies, and new chemoprevention antimalarials
Understanding heterogeneities in the epidemiology of malaria in Papua New Guinea (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/understanding-heterogeneities-in-the-epidemiology-of-malaria-in-papua-new-guinea
Background Malaria has been endemic across most parts of Papua New Guinea (PNG) at endemicity levels comparable to sub-Saharan Africa. The National Malaria Control Program (NMCP) has managed to substantially [...] impact of malaria control interventions and underlying secular trends. Drivers of change, and reasons for differences between sites will be investigated. 2) Geo-referenced data on clinical malaria cases will [...] ongoing mathematical modelling of heterogeneities in malaria dynamics at...
Estimating the extent, patterns and consequences of heterogeneity in malaria dynamics (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/estimating-the-extent-patterns-and-consequences-of-heterogeneity-in-malaria-dynamics
Background The uneven distribution of malaria is apparent on a small scale, within a single study site or even cluster of houses. Transmission varies with mosquito densities related to breeding sites, [...] relatively high transmission, have been identified. Heterogeneity has implications for many areas of malaria epidemiology, not least the design of intervention strategies. Whilst the existence of heterogeneity [...] heterogeneity, and inform the design of control strategies and the...
NETCELL Phase 5 - Core support to the National Malaria Control Programme in Tanzania (Projects)
https://www.swisstph.ch/fr/projects/project-detail/project/netcell-phase-5-core-support-to-the-national-malaria-control-programme-in-tanzania
Since its inception in 2002 the NETCELL Project has played a key role in supporting the National Malaria Control Programme (NMCP) of the Tanzanian Ministry of Health and Social Welfare, by managing the [...] Insecticide Treated Net (NATNETS) Programme. Over 200 million dollars of international donor funding for malaria prevention have been leveraged for the MoHSW in the past decade, and the NATNETS programme has been [...] focus on technical advice and strategic support; 2) an extension of...