Impact of climate variability on the transmission risk of malaria in northern Côte d'Ivoire (Publications)
climate patterns might affect the transmission of malaria. The purpose of this study was to analyze climate and environmental parameters associated with malaria transmission in Korhogo, a city in northern Cote [...] (95% CI: 0.1 to 6.7%) in clinical malaria episodes. A 0.1 unit increase in monthly NDVI was associated with a 7.3% (95% CI: 0.8 to 14.1%) increase in the monthly malaria count. There was a similar increase [...] 2.3% to 11.2%)). The study results can be used to establish a malaria...
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
The present project aimed at evaluating the safety and immunogenicity of P27A peptide vaccine in malaria non-exposed European and exposed African adults. Methods: This study was designed as a staggered [...] GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed and 40 exposed subjects on days 0, 28 and 56. Local and systemic adverse events (AEs) [...] an ADCI dependent mechanism. Incidence of AEs and antibody responses were...
Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time [...] time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at [...] and controls. Antibody responses to Pf circumsporozoite protein were...
UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria (Publications)
drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, [...] single-exposure radical cure and prophylaxis (SERCaP) to treat, prevent and block the transmission of malaria.
Challenges in malaria management and a glimpse at some nanotechnological approaches (Publications)
formulate a potent malaria vaccine need to be addressed with new strategies to achieve the final goal of malaria eradication. Nanotechnology-researching and designing innovative structures at the nanoscale-is [...] the case of malaria, nanotechnology provides tools to design strategies to target drug molecules to specific stages of the parasite, treat drug-resistant parasites, resolve severe malaria, increase vaccine [...] vaccine efficacies and combinations thereof. This chapter introduces mala...
Appropriateness of malaria diagnosis and treatment for fever episodes according to patient history and anti-malarial blood measurement: a... (Publications)
survey took place between May and August 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples were collected by dried blood spots through [...] testing when individuals attended care was defined as a patient with history of fever being tested for malaria and appropriate treatment as (i) having anti-malarial in the blood if the test result was positive [...] care and improve compliance to test result in order to target febrile...
Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against <em>Schistosoma mansoni</em> (Publications)
development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis
GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing (Publications)
Malaria is caused by Plasmodium parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only forms able to infect the mosquito vector [...] vector and transmit malaria. Sexual commitment is triggered by activation of AP2-G, the master transcriptional regulator of gametocytogenesis. Heterochromatin protein 1 (HP1)-dependent silencing of ap2-g