Mapping and predicting malaria transmission in the People's Republic of China, using integrated biology-driven and statistical models (Publications)
humidity, which thus determines the extent of malaria transmission. However, in regions with relative humidity > 60%, temperature is the major driver of malaria transmission intensity. By integrating bio [...] The purpose of this study was to deepen our understanding of Plasmodium vivax malaria transmission patterns in the People's Republic of China (P.R. China). An integrated modeling approach was employed [...] and statistical models. A Delphi approach was used to determine environmental...
Malaria seasonality and rainfall seasonality in Sri Lanka are correlated in space (Publications)
seasonality of malaria and seasonality of rainfall was studied in Sri Lanka. A simple seasonality index was developed by making use of the bimodal seasonality of both malaria and rainfall. The malaria seasonality [...] rainfall seasonality index in explaining the malaria seasonality index was found to be significant. The results suggest that rainfall is an important driver of malaria seasonality
Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated <em>Plasmodium... (Publications)
Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated malaria in the second and third trimesters of pregnancy. Its efficacy during pregnancy has recently been challenged due to altered [...] and assess their therapeutic outcome. Thirty-three pregnant women and 22 nonpregnant women with malaria were treated with AL (80/480 mg) twice daily for 3 days. All patients provided five venous plasma [...] this group, mostly due to lower posttreatment prophylaxis. Hence, a modified...
Heterochromatin protein 1 secures survival and transmission of malaria parasites (Publications)
variant expression of surface antigens allows the malaria parasite Plasmodium falciparum to evade immune recognition during blood stage infection and secure malaria transmission. We demonstrate that heterochromatin [...] have major implications for developing antidisease and transmission-blocking interventions against malaria.
Asymptomatic malaria infections: detectability, transmissibility and public health relevance (Publications)
even in low-endemic areas. In this Opinion article, we describe the detectability of asymptomatic malaria infections and the relevance of submicroscopic infections for parasite transmission to mosquitoes [...] deployment of molecular diagnostic tools is needed to provide adequate insight into the epidemiology of malaria and infection dynamics to aid elimination efforts