Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with... (Publications)
of young children with uncomplicated malaria. METHODS: We did a randomised non-inferiority study on children weighing 5-35 kg with uncomplicated P falciparum malaria in Benin, Kenya, Mali, Mozambique, and
Ecological drivers of <em>Mansonella perstans</em> infection in Uganda and patterns of co-endemicity with lymphatic filariasis and malaria (Publications)
BACKGROUND: Mansonella perstans is a widespread, but relatively unknown human filarial parasite transmitted by Culicoides biting midges. Although it is found in many parts of sub-Saharan Africa, only
Low prevalence of <em>Plasmodium</em> and absence of malaria transmission in Conakry, Guinea: prospects for elimination (Publications)
to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors [...] using the VecTest malaria panel assay and an enzyme-linked immunosorbent assay. A systematic research of Ministry of Health statistical yearbooks was performed to determine malaria prevalence in children [...] infection in Anopheles gambiae s.l. in the city of Conakry, Guinea, and...
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
would accelerate the finding of new starting points for drug discovery. The Medicines for Malaria Venture Malaria Box is a collection of over 400 compounds representing families of structures identified [...] in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite. The set has now been distributed to almost 200 research groups globally in the last two [...] domain. This paper reports for the first time on 236 screens that have been...
Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved <em>Plasmodium falciparum</em>... (Publications)
Controlled human malaria infection (CHMI) by mosquito bite has been used to assess new anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes by feeding
Mapping hotspots of malaria transmission from pre-existing hydrology, geology and geomorphology data in the pre-elimination context of Zanzibar,... (Publications)
BackgroundLarval source management strategies can play an important role in malaria elimination programmes, especially for tackling outdoor biting species and for eliminating parasite and vector populations [...] larval source management requires tools for identifying geographic foci of vector proliferation and malaria transmission where these efforts may be concentrated. Previous studies have relied on surface topographic [...] examine the relationship between dry and wet season spatial...
Estimating malaria burden in Nigeria: a geostatistical modelling approach (Publications)
This study has produced a map of malaria prevalence in Nigeria based on available data from the Mapping Malaria Risk in Africa (MARA) database, including all malaria prevalence surveys in Nigeria that [...] correlating with malaria presence were land surface temperature for day and rainfall. It was also found that malaria prevalence increased with distance to water bodies up to 4 km. The malaria risk map estimated [...] low malaria prevalence were found to be scattered around the country with...