Sustained malaria control over an 8-year period in Papua New Guinea: the challenge of low-density asymptomatic <em>Plasmodium</em> infections (Publications)
Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of [...] has resulted in reduced malaria transmission potential, but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control.
malERA: an updated research agenda for combination interventions and modelling in malaria elimination and eradication (Publications)
number of countries embarking on malaria elimination programmes, national and local decisions to select combinations of tools and deployment strategies directed at malaria elimination must address rapidly [...] This paper summarises key advances and priorities since the 2011 presentation of the Malaria Eradication Research Agenda (malERA), with a focus on the combinations of intervention tools and strategies [...] deployment against a heterogeneous transmission background is a challenge. Further...
malERA: an updated research agenda for characterising the reservoir and measuring transmission in malaria elimination and eradication (Publications)
key advances in defining the infectious reservoir for malaria and the measurement of transmission for research and programmatic use since the Malaria Eradication Research Agenda (malERA) publication in 2011 [...] is variable. New and improved measures of transmission need to be operationally feasible for the malaria programmes. Outputs from these research priorities should allow the development of a set of approaches
malERA: an updated research agenda for health systems and policy research in malaria elimination and eradication (Publications)
effectiveness of interventions ('effectiveness decay'), and respond to dynamic and changing needs. The malaria eradication research agenda (malERA) Refresh consultative process for the Panel on Health Systems [...] Research identifies opportunities to build health systems evidence and the tools needed to eliminate malaria from different zones, countries, and regions and to eradicate it globally. The research questions [...] include delivery strategies to meet the changing dynamics of needs of...
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein (Publications)
with attenuated Plasmodium falciparum sporozoites (PfSPZs) has been shown to be protective against malaria, but the features of the antibody response induced by this treatment remain unclear. To investigate [...] repeated injection of Sanaria PfSPZ Vaccine and who were found to be protected from controlled human malaria infection with infectious homologous PfSPZs. All isolated IgG monoclonal antibodies bound to P.
A review of spatial epidemiology with malaria surveillance and control in China (Publications)
monitoring and control of malaria depends largely on the spatial analysis technology and mathematical models. Visualization of malaria situation is the most popular way to present how malaria transmits. In this [...] paper, the malaria epidemic situation and the application of spatial epidemiology of malaria in China are summarized, so as to provide the systematic epidemiological information for malaria elimination
Small-scale field evaluation of push-pull system against early- and outdoor-biting malaria mosquitoes in an area of high pyrethroid resistance in... (Publications)
mortality in push-pull contexts. This approach, if optimised, could potentially complement existing malaria interventions even in areas with high pyrethroid resistance.
Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)
antibodies are induced following immunization of malaria pre-exposed volunteers with PfSPZ Vaccine. We found that in addition to anti-PfCSP IgG, Malaria pre-exposed volunteers developed anti-PfCSP IgM [...] and Pf sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria pre-exposed individuals and that IgM antibodies can inhibit Pf sporozoite invasion into hepatocytes
Human migration and the spread of malaria parasites to the New World (Publications)
We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant [...] contribution of African and South Asian lineages to present-day New World malaria parasites with additional P. vivax lineages appearing to originate from Melanesia that were putatively carried by the