Effects of climate variability on malaria transmission in southern Côte d'Ivoire, West Africa (Publications)
variables and malaria transmission in Côte d’Ivoire. We used the VECTRI model to predict malaria transmission in southern Côte d’Ivoire. First, we tested the suitability of VECTRI in modeling malaria transmission [...] Malaria continues to be a major public health concern with a substantial burden in Africa. Even though it has been widely demonstrated that malaria transmission is climate-driven, there have been very [...] rate (EIR) from the VECTRI model was well correlated with the observed mal...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Delayed cerebellar ataxia induced by <em>Plasmodium falciparum</em> malaria: a rare complication (Publications)
KEY CLINICAL MESSAGE: In endemic areas, malaria-induced cerebellar ataxia should be suspected in patients presenting with neurological disorders including slurred speech, tremors, and a sense of imbalance [...] ions, investigations, and outcomes of a patient developed delayed cerebellar ataxia following a malaria infection: an unusual complication of the disease. This report highlights the diagnostic challenges
Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo (Publications)
BACKGROUND: Malaria remains a major public health issue in the Democratic Republic of the Congo (DRC), accounting for 44% deaths among outpatient visits in children
The MTego trap: a potential tool for monitoring malaria and arbovirus vectors (Publications)
used interchangeably with the BGP trap for sampling anthropophilic mosquitoes including African malaria vectors An. gambiae and An. funestus and the principal arbovirus vector Ae. aegypti.
Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda (Publications)
than five years with suspected severe malaria. An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days after [...] Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always
Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania (Publications)
probability of malaria TPR exceeding programmatic threshold was estimated. Results showed a marked spatial heterogeneity in malaria TPR across wards. 17.7 million people resided in areas where malaria TPR was [...] As malaria transmission declines, the need to monitor the heterogeneity of malaria risk at finer scales becomes critical to guide community-based targeted interventions. Although routine health facility [...] million people lived in areas where malaria TPR was very low ( < 5%; 90%...
Testing and treatment for malaria elimination: a systematic review (Publications)
BACKGROUND: Global interest in malaria elimination has prompted research on active test and treat (TaT) strategies. METHODS: A systematic review and meta-analysis were conducted to assess the effectiveness [...] effectiveness of TaT strategies to reduce malaria transmission. RESULTS: A total of 72 empirical research and 24 modelling studies were identified, mainly focused on proactive mass TaT (MTaT) and reactive case [...] respectively. Ten intervention studies compared MTaT to no MTaT and the...