A <em>Plasmodium falciparum</em> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface (Publications)
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane [...] formation and the associated iRBC adherence to host endothelium are directly linked to the severity of malaria and are functional manifestations of protein export from the parasite to the iRBC. A family of exported
Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers <em>msp</em>-1,... (Publications)
BACKGROUND: Drug efficacy trials monitor the continued efficacy of front-line drugs against falciparum malaria. Over-estimates of efficacy result in a country retaining a failing drug as first-line treatment [...] modelling to simulate parasite dynamics and genetic signals that occur in patients enrolled in malaria drug clinical trials. We compared estimates of treatment failure obtained from a selection of proposed
qRT-PCR versus IFA-based quantification of male and female gametocytes in low-density <em>Plasmodium falciparum</em> infections and their relevance... (Publications)
Accurate quantification of female and male gametocytes and sex ratios in asymptomatic low-density malaria infections are important for assessing their transmission potential. Gametocytes often escape detection [...] negligible for human-to-mosquito transmission.Estimating the transmission potential of ultralow-density malaria infections informs interventions. Almost all infections with > /=1 female and male gametocyte per
The three <em>Plasmodium falciparum </em>Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual... (Publications)
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialised mode of cell division ch [...] throughout schizogony as well as in the non-dividing gametocyte stages, which are essential for malaria transmission. We demonstrate that all three PfARKs display distinct and highly specific and exclusive
A worldwide map of <em>Plasmodium falciparum</em> K13-propeller polymorphisms (Publications)
BACKGROUND: Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. [...] analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel
Two successful decades of Swiss collaborations to develop new anti-malarials (Publications)
Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives of children throughout the world. In addition [...] Third, the emergence of product-development-partnerships, in this case led by the Medicines for Malaria Venture, based in Geneva, has helped to catalyze the development of new medicines and bring the community
Safety of artemether-lumefantrine exposure in first trimester of pregnancy: an observational cohort (Publications)
s in early pregnancy. They are, therefore, not recommended by WHO as a first-line treatment for malaria in first trimester due to associated embryo-foetal toxicity in animal studies. The study assessed
Quest for a potent antimalarial drug lead: synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines (Publications)
activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, we have synthesized approximately 150 different 6,7-dimethoxyquinazoline-2,4-diamines
Epidemiology of community-onset bloodstream infections in Bouaké, central Côte d'Ivoire (Publications)
and symptoms were not significantly associated with blood culture positivity after controlling for malaria.
Antiparasitic chaiyaphumines from entomopathogenic <em>Xenorhabdus</em> sp. PB61.4 (Publications)
(1) showed good activity against Plasmodium falciparum (IC50 of 0.61 muM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents