In vitro antiplasmodial activity and cytotoxicity of ethnobotanically selected Ivorian plants (Publications)
Eight extracts from four Ivorian medicinal plants, traditionally used to treat malaria, were tested for their antiplasmodial activity in vitro by assessing their ability to inhibit the uptake of [3H]h
Causes of fever in returning travelers: a European multicenter prospective cohort study (Publications)
diagnostic algorithm was used ensuring a systematic evaluation of all participants. After ruling out malaria, PCRs and serologies for dengue, chikungunya and Zika viruses were performed in all patients presenting
Synthesis of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities (Publications)
The new compounds were tested for their activities against one strain of the causative organism of Malaria tropica, Plasmodium falciparum K1, which is resistant against chloroquine and pyrimethamine. In addition
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
Estimation of the antirelapse efficacy of tafenoquine, using <em>Plasmodium vivax</em> genotyping (Publications)
Plasmodium vivax relapse prevention is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled Phase IIb study in Peru, India, Thailand
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies (Publications)
were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis
Mass distribution of free insecticide-treated nets do not interfere with continuous net distribution in Tanzania (Publications)
BACKGROUND: To protect the most vulnerable groups from malaria (pregnant women and infants) the Tanzanian Government introduced a subsidy (voucher) scheme in 2004, on the basis of a public-private partnership [...] for the continuation of this effort in Tanzania and for emulation by other countries with endemic malaria