<em>In vitro</em> antiplasmodial activity and cytotoxicity of extracts and chromatographic fractions of twigs from <em>Pappea capensi</em>s EckI &... (Publications)
The Vha-Venda people of South Africa use Pappea capensis EckI & Zeyh. (Sapindaceae) twigs to treat malaria and its related symptoms. AIM OF STUDY: The main aim of this study was to evaluate the antiplasmodial [...] in P. capensis twigs. CONCLUSION: The study validates the ethnomedicinal use of P. capensis for malaria treatment. It demonstrated the potential of discovering novel antiplasmodial constituents that could
Inclusion of health in impact assessment: a review of current practice in sub-Saharan Africa (Publications)
health determinants and included health outcomes were often limited to a few aspects, such as HIV, malaria and injuries. The miniscule yield of reports (1.6% of contacted projects) and the low response rate
Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in <em>Anopheles arabiensis</em> sampled from an... (Publications)
compromise the use of insecticides for the control of vector-borne diseases. The tolerance of the malaria vector, Anopheles arabiensis to deltamethrin was determined in a field population from a cotton-growing
3D imaging of undissected optically cleared <em>Anopheles stephensi </em>mosquitoes and midguts infected with <em>Plasmodium</em> parasites (Publications)
Malaria is a life-threatening disease, caused by Apicomplexan parasites of the Plasmodium genus. The Anopheles mosquito is necessary for the sexual replication of these parasites and for their transmission
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
the toolbox for drug discovery for protozoal diseases such as human African trypanosomiasis and malaria. The method could probably be adapted to other protozoan parasites, especially those growing ext
Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified
New antiparasitic flexible triaryl diamidines, their prodrugs and aza analogues: synthesis, <em>in vitro</em> and<em> in vivo</em> biological... (Publications)
potent antiparasitic agents with proven activity against tropical diseases like trypanosomiasis and malaria. This work presents the synthesis of new mono and diflexible triaryl amidines (6a-c, 13a,b and 17)
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in <em>Plasmodium... (Publications)
artemisinin-based combination therapy (ACT) recommended as first-line treatment of Plasmodium falciparum malaria in disease-endemic countries. Studies by Eckstein-Ludwig and co-workers showed both thapsigargin
Morbidity due to <em>Schistosoma mansoni</em>: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with... (Publications)
chronically evolved morbidity and/or that other interacting factors were involved, e.g. malnutrition and malaria. At 1-year follow-up, ACR scores showed an overall trend of regression towards the mean, potentially
Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua... (Publications)
key factor driving drug resistance and reduced treatment effectiveness in Plasmodium falciparum malaria, but there are few formal, quantitative analyses of this process. METHODS. We analyzed drug usage