Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children (Publications)
seasonality, proportions of malaria fevers treated and drug characteristics. METHODS: We use a dynamic, individual-based simulation model of Plasmodium falciparum malaria epidemiology, antimalarial drug [...] preventive treatment in infants (IPTi) and children (IPTc) have shown promising results in reducing malaria episodes but with varying efficacy and cost-effectiveness. The effects of different intervention [...] g and more expensive drugs, high frequencies of drug resistance and high levels...
Safety of falciparum malaria diagnostic strategy based on rapid diagnostic tests in returning travellers and migrants: a retrospective study (Publications)
developed severe malaria while 6/137 of both RDT and BS positive did so. The use of RDT allowed a reduction of a median of 2.1 hours to get a first malaria test result.CONCLUSIONS: A malaria diagnostic strategy [...] tests for malaria (RDT) allow accurate diagnosis and prompt treatment. Validation of their usefulness in travellers with fever was needed. The safety of a strategy to diagnose falciparum malaria based on [...] those, 2/2028 (0.1%) developed uncomplicated malaria with both RDT and BS...
Experience and challenges from clinical trials with malaria vaccines in Africa (Publications)
clinical trials and malaria control programmes as part of the Global Malaria Action Plan (GMAP). GMAP outlined and support global strategies toward the elimination and eradication of malaria in many areas, [...] Malaria vaccines are considered amongst the most important modalities for potential elimination of malaria disease and transmission. Research and development in this field has been an area of intense effort [...] Despite this, there is currently no licensed malaria vaccine. Researchers,...
Generalized seasonal autoregressive integrated moving average models for count data with application to malaria time series with low case numbers (Publications)
The models were applied to monthly malaria case time series in a district in Sri Lanka, where malaria has decreased dramatically in recent years. RESULTS: The malaria series showed long-term changes in [...] INTRODUCTION: With the renewed drive towards malaria elimination, there is a need for improved surveillance tools. While time series analysis is an important tool for surveillance, prediction and for measuring [...] on in the series. CONCLUSIONS: G(S)ARIMA models may be particularly useful...
Malaria surveillance-response strategies in different transmission zones of the People's Republic of China: preparing for climate change (Publications)
understanding of malaria transmission patterns in the People's Republic of China (P.R. China) is crucial for designing effective surveillance-response strategies that can guide the national malaria elimination [...] survival derived from monthly mean temperature and YRH were generated. For each decade, the final malaria prediction map was overlaid by two mask maps, in terms of number of months suitable for parasite [...] 60%. RESULTS: Considering multiple environmental factors simultaneously,...
Towards malaria elimination: a new thematic series (Publications)
launch of a new thematic series of Malaria Journal -- "Towards malaria elimination" -- creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic
Incorporating operational research in programmes funded by the Global Fund to Fight AIDS, Tuberculosis and Malaria in four sub-Saharan African... (Publications)
situation analysis of the extent to which grants from the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund) are being utilized to support operational research and implementation research (OR/IR) [...] both via telephone/online conference tools and in person in four countries with a high burden of malaria and tuberculosis. These countries were Ghana, Sierra Leone, the United Republic of Tanzania and Zimbabwe
Patterns of pesticide usage in agriculture in rural Tanzania call for integrating agricultural and public health practices in managing... (Publications)
and malaria vector control, poor pesticide management practices and low-levels of awareness among farmers and pesticides retailers might enhance the selection of insecticide resistance in malaria vectors
PfMAP-2 is essential for male gametogenesis in the malaria parasite<em> Plasmodium falciparum</em> (Publications)
In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alternating [...] induction of axoneme motility. However, in P. falciparum, causing the most severe form of human malaria, PfMAP-2 was suggested to be essential for asexual proliferation indicating distinct functions for