From strategy development to routine implementation: the cost of Intermittent Preventive Treatment in Infants for malaria control (Publications)
Saharan Africa. Intermittent Preventive Treatment in infants (IPTi) is a promising new tool for malaria control. Although efficacy information is available for many interventions, there is a dearth of
Target product profile choices for intra-domiciliary malaria vector control pesticide products: repel or kill? (Publications)
BACKGROUND: The most common pesticide products for controlling malaria-transmitting mosquitoes combine two distinct modes of action: 1) conventional insecticidal activity which kills mosquitoes exposed [...] mosquitoes to non-users rather than killing them outright. METHODS: A process-explicit model of malaria transmission is described which captures the sequential interaction between deterrent and toxic actions
Spatio-temporal malaria transmission patterns in Navrongo demographic surveillance site, northern Ghana (Publications)
BACKGROUND: The relationship between entomological measures of malaria transmission intensity and mortality remains uncertain. This is partly because transmission is heterogeneous even within small ge [...] analysed data from Kassena-Nankana districts in northern Ghana to obtain small area estimates of malaria transmission rates allowing for this uncertainty.METHODS: Independent Bayesian geostatistical models [...] mosquito densities.CONCLUSION: This study confirms the presence of...
Spatio-temporal analysis of the role of climate in inter-annual variation of malaria incidence in Zimbabwe (Publications)
inter-annual variation in malaria incidence. Quantitative description of the space-time effect of this association has practical implications for the development of operational malaria early warning system [...] system (MEWS) and malaria control. We used Bayesian negative binomial models for spatio-temporal analysis of the relationship between annual malaria incidence and selected climatic covariates at a district level [...] 1988-1999. RESULTS: Considerable inter-annual variations were observed...
Modelling the epidemiological impact of intermittent preventive treatment against malaria in infants (Publications)
preventive treatment against malaria in infants (IPTi) using sulphadoxine-pyrimethamine (SP) have shown a positive, albeit variable, protective efficacy against clinical malaria episodes. The impact of IPTi [...] periods. The predicted cumulative benefits were proportionately slightly greater for severe malaria episodes and malaria-attributable mortality than for acute episodes in the settings modelled. Modest increased [...] mortality. METHODS/PRINCIPAL FINDINGS: We used a comprehensive,...
Mapping malaria risk among children in Côte d'Ivoire using Bayesian geo-statistical models (Publications)
estimated 767,000 disability-adjusted life years are due to malaria, placing the country at position number 14 with regard to the global burden of malaria. Risk maps are important to guide control interventions [...] ons, and hence, the aim of this study was to predict the geographical distribution of malaria infection risk in children aged
Epidemiology and clinical features of vivax malaria imported to Europe: sentinel surveillance data from TropNetEurop (Publications)
Plasmodium vivax is the second most common species among malaria patients diagnosed in Europe, but epidemiological and clinical data on imported P. vivax malaria are limited. The TropNetEurop surveillance network [...] network has monitored the importation of vivax malaria into Europe since 1999. OBJECTIVES: To present epidemiological and clinical data on imported P. vivax malaria collected at European level. MATERIAL AND [...] AND METHODS: Data of primary cases of P. vivax malaria reported...
Implementation of an insecticide-treated net subsidy scheme under a public-private partnership for malaria control in Tanzania--challenges in... (Publications)
commitments from organizations such as the Global Fund for HIV/AIDS, Tuberculosis and Malaria (GFATM), the President's Malaria Initiative and the World Bank Booster programme. METHODS: The case study uses the [...] BACKGROUND: In the past decade there has been increasing visibility of malaria control efforts at the national and international levels. The factors that have enhanced this scenario are the availability [...] implementation of a public-private partnership approach embarked upon by the...
Ecologists can enable communities to implement malaria vector control in Africa (Publications)
BACKGROUND: Integrated vector management (IVM) for malaria control requires ecological skills that are very scarce and rarely applied in Africa today. Partnerships between communities and academic ecologists [...] programme at grassroots level, which was subsequently upgraded and expanded into a pilot scale Urban Malaria Control Programme with support from national academic institutes. RESULTS: Both programmes now access [...] ed implementation and operational research opportunities. The...
Genetic diversity of expressed <em>Plasmodium falciparum</em> var genes from Tanzanian children with severe malaria (Publications)
BACKGROUND: Severe malaria has been attributed to the expression of a restricted subset of the var multigene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 [...] in Tanzanian children was analysed. METHODS: Children with defined severe (SM) and asymptomatic malaria (AM) were recruited. Fulllength var mRNA was isolated and reversed transcribed into var cDNA. Su