Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
we aim for a dual action with drug- and 'vaccine-like' activity against malaria. By inhibiting entry of malaria parasites into host red blood cells (RBCs) - using polymer vesicle-based (polymersome) nanomimics [...] formed with the same block copolymers as nanomimics, also bind the corresponding malaria parasite ligand and whole malaria parasites, similar to nanomimics. This was demonstrated using fluorescence imaging [...] Malaria is an infectious disease that needs to be addressed using...
Two-year evaluation of Intermittent Preventive Treatment for Children (IPTc) combined with timely home treatment for malaria control in Ghana (Publications)
timely treatment of febrile malaria illness, is effective to reduce malaria parasite prevalence in children aged 6 to 60 months in the study community. This must give hope to malaria control programme managers [...] accepted as an important component of the malaria control strategy. Intermittent preventive treatment for children (IPTc) combined with timely treatment of malaria related febrile illness at home to reduce [...] reduce parasite prevalence and malaria morbidity in children aged...
The synthetic<em> Plasmodium falciparum</em> circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial (Publications)
Plasmodium falciparum circumsporozoite protein (PfCS102) in malaria naive adults. METHODOLOGY AND PRINCIPAL FINDINGS: Thirty-six healthy malaria-naive adults were randomly distributed into three dose blocks [...] BACKGROUND: Fully efficient vaccines against malaria pre-erythrocytic stage are still lacking. The objective of this dose/adjuvant-finding study was to evaluate the safety, reactogenicity and immunogenicity
The architecture and effect of participation: a systematic review of community participation for communicable disease control and elimination.... (Publications)
successful disease control and elimination campaigns in many countries. Despite this, its benefits for malaria control and elimination are yet to be fully realized. This may be due to a limited understanding [...] participation for communicable disease control and elimination and provide guidance for the current malaria elimination campaign. METHODS: Evidence derived from quantitative research was considered both i [...] communicable disease control and elimination which is presented herein....
Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control (Publications)
awaiting for the arrival of an effective and affordable malaria vaccine, there is a need to make use of the available control tools to reduce malaria risk, especially in children under five years and pregnant [...] important component of the malaria control strategy. This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness [...] of febrile malaria illness, impacts significantly on the parasite...
Improvements in access to malaria treatment in Tanzania following community, retail sector and health facility interventions - a user perspective (Publications)
Treatment-seeking and awareness of malaria was already high at baseline, but various improvements were seen between 2004 and 2008, namely: better understanding causes of malaria (from 62% to 84%); an increase [...] approach aimed at improving understanding and treatment of malaria has led to tangible improvements in terms of people's actions for the treatment of malaria. However, progress was hindered by the low availability [...] BACKGROUND: The ACCESS programme aims at understanding and...
Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug... (Publications)
Dispensing Outlets (ADDO) was created in Tanzania. Tanzania changed its first-line treatment for malaria from sulphadoxine-pyrimethamine (SP) to artemether-lumefantrine (ALu) in 2007. Subsidized ALu was [...] made available in both health facilities and ADDOs. The effect of these interventions on access to malaria treatment was studied in rural Tanzania. METHODS: The study was carried out in the villages of Kilombero [...] outlets. The data were complemented with DSS population data. RESULTS:...
Models for short term malaria prediction in Sri Lanka (Publications)
time series of district malaria cases for their ability to predict the number of malaria cases one to four months ahead. The addition of covariates such as the number of malaria cases in neighbouring districts [...] monitored/diagnosed malaria cases allows for the study of forecasting models, with an aim to developing a forecasting system which could assist in the efficient allocation of resources for malaria control. METHODS: [...] BACKGROUND: Malaria in Sri Lanka is unstable and fluctuates in...