Role of human Pegivirus infections in whole <em>Plasmodium falciparum </em>sporozoite vaccination and controlled human malaria infection in African... (Publications)
protection in African volunteers undergoing whole P. falciparum sporozoites-based malaria vaccination and controlled human malaria infections (CHMI). METHODS: HPgV-1 prevalence was quantified by RT-qPCR in plasma [...] levels among different populations pose a serious challenge to the development of an effective malaria vaccine. Co-infections are among many factors associated with immune dysfunction and sub-optimal
Bayesian spatial models applied to malaria epidemiology (Publications)
scaling-up. Contemporary information on malaria prevalence for this work was provided mostly by Malaria Indicator Surveys (MIS) and Demographic Health Surveys (DHS) with malaria modules. MIS are nationally rep [...] impressive increases in international funding for malaria prevention, control, and elimination, which have led to tremendous expansion in implementing national malaria control programs (NMCPs). Common interventions [...] (MDG) 6 aims to halve malaria incidence by 2015 as compared to...
Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines (Publications)
Malaria is a life-threatening epidemic disease with half of the world's population at risk. Although its incidence rate has fallen since 2010, this ratio dramatically stalled between 2014 and 2018. New [...] molecules in serum samples. The immunoassay successfully diagnoses humoral immune responses induced by malaria vaccine candidates and reveals the timeline and stage of the infection. We applied the newly developed [...] antibody/vaccine solutions, to blood samples from clinical trials on...
Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and... (Publications)
offers a tool for further studies on epigenetic regulation and life cycle decision in malaria parasites.IMPORTANCE Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate [...] The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes [...] domain and CSD of HP1 are functionally conserved between P....
Comparative assessment of insecticide resistance phenotypes in two major malaria vectors, <em>Anopheles funestus</em> and <em>Anopheles... (Publications)
Long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS) have greatly reduced malaria transmission in sub-Saharan Africa, but are threatened by insecticide resistance. In south-eastern [...] rn Tanzania, pyrethroid-resistant Anopheles funestus are now implicated in > 80% of malaria infections, even in villages where the species occurs at lower densities than the other vector, Anopheles arabiensis [...] arabiensis. This study compared the insecticide resistance phenotypes...
Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin? (Publications)
the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chem [...] several days had elapsed between onset of symptoms and diagnosis. The importance of information on malaria to tourists and physicians is stressed.
Epidemiologie und Klinik der Malaria in der Schweiz (Publications)
thirds of all cases of malaria in Switzerland are imported from Africa. Accordingly, malignant malaria is more frequently diagnosed in Switzerland than tertian malaria. Malignant malaria usually presents atypically [...] shock. The lethality is high. The majority of Swiss travellers are not protected effectively against malaria. A group particularly at risk are tourists of 20--30 years of age. It is suggested that travel agencies [...] the medical profession should intensify public information...
Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria (Publications)
quinidine, usually stocked by hospitals, is an alternative drug for malaria treatment. We report the cases of two patients with severe malaria imported from Kenya. They were treated first with intravenous quinidine [...] Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug [...] mg/kg b.w./die of quinidine given intravenously seems to be an adequate...
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the [...] vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose [...] against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the...