Malaria mapping using transmission models: application to survey data from Mali (Publications)
to age-specific malaria prevalence. The approach makes more efficient use of the available data than do previous malaria mapping methods, and it produces highly plausible maps of malaria distribution [...] Geographic mapping of the distribution of malaria is complicated by the limitations of the available data. The most widely available data are from prevalence surveys, but these surveys are generally carried [...] approach to the analysis of survey data from Mali, collected in 1965-1998,...
Asexual blood-stage malaria vaccine development: facing the challenges (Publications)
reduce morbidity. RECENT FINDINGS: There is good rationale to support the development of blood-stage malaria vaccines, the most promising being the demonstration that nonimmune volunteers repeatedly challenged [...] as well as the demonstration of the efficacy of the first asexual blood-stage vaccine tested in a malaria endemic area (combination B) to reduce parasite density in children. The selective pressure induced
Malaria and casual sex: what travelers know and how they behave (Publications)
Results: Compliance with chemosuppressive regimen for malaria was 87%. Well-informed travelers did not protect themselves more efficiently against malaria. The efficacy of a given intervention was found to [...] Background: Travelers to the tropics have been reported to comply poorly with recommendations regarding malaria and AIDS. This study addresses the problem of influencing travelers' behavior through different [...] implications of "sex tourism" and the possibility of participating in a...
Safety and immunogenicity of a three-component blood-stage malaria vaccine in adults living in an endemic area of Papua New Guinea (Publications)
A Phase I safety and immunogenicity study with a three-component blood- stage malaria vaccine was conducted in adult male subjects living in an endemic area of Papua New Guinea. The preparations were
Malaria: burden of disease (Publications)
large parts of the planet. The failed attempt to eradicate malaria gave way to the control policy that was followed by a huge resurgence of malaria during the late 70s and 80s. Together with the emergence [...] plasmodium species and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission [...] living at risk has grown to about 3 billion, and is expected to go on...
Humoral immune responses during a malaria vaccine trial in Tanzanian infants (Publications)
The development of a malaria vaccine is a priority for improved and sustained malaria control. Optimal use of a vaccine in Africa will only be achieved if it can be delivered through the Expanded Programme [...] preimmunization levels by 2 years of age and which was not associated with protection against clinical malaria. The vaccine induced no IgG antibodies against (NANP)50 or P. falciparum lysates. SPf66 stimulated
Malaria vaccines: from the laboratory to the field (Publications)
cure of malaria patients with passive transfer of specific immunoglobulins, and iii) protection conferred by vaccination with sporozoites attenuated by radiation, justifies the search for a malaria vaccine [...] include recombinant proteins, synthetic peptides and DNA vaccines, the relevant genes encoding malaria antigens being inserted into a plasmid or a live vector such as vaccinia or poxvirus. A number of [...] Combination B) had an efficacy of 62% in reducing parasite density in Papua New...