Managing the sick child in the era of declining malaria transmission: development of ALMANACH, an electronic algorithm for appropriate use of... (Publications)
based on a respiratory rate threshold of 50 assessed twice for febrile children 12-59 months; iv) malaria rapid diagnostic test performed for all febrile children. In the absence of identified source of
Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study (Publications)
Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not [...] shifting of incidence induced by either pre-erythrocytic vaccination (PEV) programmes or seasonal malaria chemo-prevention (SMC), using an ensemble of individual-based stochastic simulation models of P. [...] life-cycle and on human demography. Effects of transmission intensity, and of...
Optimization of potent inhibitors of <em>P. falciparum</em> dihydroorotate dehydrogenase for the treatment of malaria (Publications)
dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum [...] but do not inhibit the human enzyme. On the basis of efficacy observed in three mouse models of malaria, acceptable safety pharmacology risk assessment and safety toxicology profile in rodents, lack of
Tod am Kilombero : Tanners Kampf gegen Malaria [TV Broadcast] (Publications)
Afrika ein Kind an Malaria, weltweit sind es Jahr für Jahr bis zu drei Millionen Menschen. Der Kampf gegen den grössten Killer der dritten Welt scheint aussichtslos. Und doch hat die Malaria einen hartnäckigen [...] einer seiner Malaria-Missionen an den Kilombero begeleitet. Der Fluss im Südwesten Tansanias verwandelt nach jeder Regenzeit ein Gebiet, so gross wie die Westschweiz, in eine wahre Malaria-Hölle. Wer hier [...] hier (über-) lebt, muss jährlich weit über 1'000 Malaria-infizierte...