Preclinical profiling of the immunogenicity of a two-component subunit malaria vaccine candidate based on virosome technology (Publications)
anti-peptide responses, augmenting the value of this system for the development of a multivalent malaria vaccine
Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation (Publications)
ozoite protein (CSP) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. We describe here the design of a conformationally constrained synthetic peptide
Environmental predictors of the seasonality of malaria transmission in Africa: the challenge (Publications)
A description of malaria seasonality is important for planning and optimizing malaria control in both time and space, but adequate malariologic data are not available for many disease-endemic areas. We [...] between the seasonal dynamics of environmental determinants and malaria pose a great challenge and highlights the need for improved models of malaria seasonality
Malaria mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites (Publications)
epidemiological differences in malaria mortality. RESULTS: Rates of malaria mortality varied by 1:10,000 across the sites, with generally low rates in Asia (one site recording no malaria deaths over 0.5 million [...] person-years). Childhood malaria mortality rates were strongly correlated with Malaria Atlas Project estimates of Plasmodium falciparum parasite rates for the same locations. Adult malaria mortality rates, while [...] BACKGROUND: Malaria continues to be a major cause of infectious...
Surveillance and response strategy in the malaria post-elimination stage: case study of Fujian province (Publications)
Malaria used to be a serious health problem in Fujian province in the past, but no local malaria transmission has been found since 2000. In order to eliminate the potential residual cases and prevent [...] re-introduction of malaria so as to achieve the final goal of malaria elimination in Fujian province, various strategy and intervention approaches were tailored to the local settings. For instance, the [...] respective. All other imported malaria cases were detected during post-elimination...
The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidity (Publications)
Malaria mortality and morbidity were studied in a rural population of 4000 in the Wosera area, East Sepik Province, Papua New Guinea. Malaria accounted for 4.9% of the 162 deaths investigated by verbal [...] at the beginning of the wet season. The geographical distribution of malaria morbidity was not uniform. The measurement of malaria-related morbidity, the identification of significant seasonal and local [...] verbal autopsy and for 12.2% of the 49 deaths assessed through medical records. Mal...
Lessons from malaria control to elimination: case study in Hainan and Yunnan provinces (Publications)
appears to be victorious in eliminating malaria. However, there is still a long way to go to prevent the reintroduction of malaria in Hainan province and eliminating malaria in the border areas of Yunnan province [...] and P. vivax malaria transmission and the role of an integrated strategy of case management and vector control are compared between different ecological zones. The epidemiology of malaria in Hainan and [...] experiences and challenges from malaria control to elimination in Hainan...