DNA sequence explains seemingly disordered methylation levels in partially methylated domains of Mammalian genomes (Publications)
For the most part metazoan genomes are highly methylated and harbor only small regions with low or absent methylation. In contrast, partially methylated domains (PMDs), recently discovered in a variet
Implementing ideal health policy in a fragile health system: the example of expanding the use of malaria rapid diagnostic tests in mainland Tanzania (Publications)
Malaria confirmation before treatment provides an opportunity for improving the quality of malaria case management in endemic regions. However, increased coverage of this strategy is facing many organ
Assessment of factors influencing retention in the Philippine National Rural Physician Deployment Program (Publications)
BACKGROUND: The 'Doctors to the Barrios' (DTTB) Program was launched in 1993 in response to the shortage of doctors in remote communities in the Philippines. While the Program has attracted physicians
A clinical prediction score in addition to WHO criteria for anti-retroviral treatment failure in resource-limited settings: experience from Lesotho (Publications)
OBJECTIVE: To assess the positive predictive value (PPV) of a clinical score for viral failure among patients fulfilling the WHO-criteria for anti-retroviral treatment (ART) failure in rural Lesotho.
The past and future of tuberculosis research (Publications)
Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, di
The influence of host and bacterial genotype on the development of disseminated disease with <em>Mycobacterium tuberculosis</em> (Publications)
The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causi
Sterilising effects of pyriproxyfen on <em>Anopheles arabiensis</em> and its potential use in malaria control (Publications)
BACKGROUND: Insecticide resistance poses a major threat to current vector control campaigns. Insecticides with novel modes of action are therefore in high demand. Pyriproxyfen (PPF), a conventional mo
A simple and efficient tool for trapping gravid <em>Anopheles</em> at breeding sites (Publications)
BACKGROUND: No effective tool currently exists for trapping ovipositing malaria vectors. This creates a gap in our ability to investigate the behavior and ecology of gravid Anopheles. FINDINGS: Here w