Disposition of mefloquine and enpiroline is highly influenced by a chronic <em>Schistosoma mansoni</em> infection (Publications)
Chronic Schistosoma mansoni infections lead to severe tissue destructions of the gut wall and liver and can influence drug disposition. This study aimed to investigate the impact of a chronic S. manso
Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms (Publications)
A night without sleep is followed by enhanced sleepiness, increased low-frequency activity in the waking EEG, and reduced vigilant attention. The magnitude of these changes is highly variable among he
Antiprotozoal activity of bicyclic diamines with a N-methylpiperazinyl group at the bridgehead atom (Publications)
omega-Aminoacyl and -alkyl derivatives of 4-(4-methylpiperazin-1-yl)bicyclo[2.2.2]octan-2-amines and of 5-(4-methylpiperazin-1-yl)-2-azabicyclo[3.2.2]nonanes were prepared and their activities were ex
Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)