Mechanistic dose-response modelling of animal challenge data shows that intact skin is a crucial barrier to leptospiral infection (Publications)
Leptospirosis is a widespread and potentially life-threatening zoonotic disease caused by spirochaetes of the genus Leptospira. Humans become infected primarily via contact with environmental reservoi
Targeting a large active site: structure-based design of nanomolar inhibitors of <em>Trypanosoma brucei </em>trypanothione reductase (Publications)
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids, the causative agents of human African trypanosomiasis (HAT), Chagas' disease, and leishmaniases. Introd
Five-year impact of different multi-year mass drug administration strategies on childhood <em>Schistosoma mansoni</em>-associated morbidity: a... (Publications)
The WHO recommends mass treatment with praziquantel as the primary approach for Schistosoma mansoni-related morbidity control in endemic populations. The Schistosomiasis Consortium for Operational Res
Safety profile of the meningococcal conjugate vaccine (Menafrivacâ„¢) in clinical trials and vaccination campaigns: a review of published studies (Publications)
The study aimed to assess the capacity of AEFI surveillance during vaccination campaigns with the new conjugate meningitis vaccine (MenAfrivac). A systematic review of studies on MenAfrivac published
Predicting fine-scale daily NO2 for 2005-2016 incorporating OMI satellite data across Switzerland (Publications)
Nitrogen dioxide (NO2) remains an important traffic-related pollutant associated with both short- and long-term health effects. We aim to model daily average NO2 concentrations in Switzerland in a mul
Health impact assessment and health equity in sub-Saharan Africa: a scoping review (Publications)
Background:Naturalresourceextractionprojectscanhavepositivebutalsonegativeeffectsonthehealthofaffectedcommunities, governed by demographic, economic, environmental, physical and social changes. Negati
Outdoor air pollution and the burden of childhood asthma across Europe (Publications)
BACKGROUND: Emerging evidence suggests that air pollution may contribute to childhood asthma development. We estimated the burden of incident childhood asthma that may be attributable to outdoor NO2,
Time-course of upper respiratory tract viral infection and COPD exacerbation (Publications)
Viral respiratory tract infections have been implicated as the predominant risk factor for acute exacerbations of COPD (AECOPD). We aimed to evaluate, longitudinally, the association between upper res
Heterologous production and functional characterization of ageritin, a novel type of ribotoxin highly expressed during fruiting of the edible mushroom... (Publications)
Fungi produce various defense proteins against antagonists including ribotoxins. These toxins cleave a single phosphodiester bond within the universally conserved sarcin-ricin loop of ribosomes and in