3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential (Publications)
A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library. T
Geschlechtsunterschiede in Gesundheit und Gesundheitsverhalten (Publications)
The higher life expectancy of women is contrasting with the higher female morbidity known from health interview surveys and statistics on use of health services. In the Swiss Health Survey SOMIPOPS, w
Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature. This led to the identification of cynaropicrin (1) fr
Effect of temperature on the development of <em>Schistosoma japonicum</em> within <em>Oncomelania hupensis</em>, and hibernation of <em>O.... (Publications)
The objectives of this investigation were to assess the effect of temperature on the development of Schistosoma japonicum harboured in Oncomelania hupensis and to determine the lowest temperature thre
Fit genotypes and escape variants of subgroup III <em>Neisseria meningitidis</em> during three pandemics of epidemic meningitis (Publications)
The genetic variability at six polymorphic loci was examined within a global collection of 502 isolates of subgroup III, serogroup A Neisseria meningitidis. Nine "genoclouds" were identified, consisti
Transmission dynamics and economics of rabies control in dogs and humans in an African city (Publications)
Human rabies in developing countries can be prevented through interventions directed at dogs. Potential cost-savings for the public health sector of interventions aimed at animal-host reservoirs shoul
The prophylactic effects of artemether against <em>Schistosoma japonicum </em>infections (Publications)
The fight against schistosomiasis in China has been very effective in reducing the number of infections across the country. However, the drug of choice, praziquantel, has no prophylactic effect, which