Vaccination with the surface proteins MUL_2232 and MUL_3720 of <em>Mycobacterium ulcerans</em> induces antibodies but fails to provide protection... (Publications)
BACKGROUND: Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a chronic ulcerative neglected tropical disease of the skin and subcutaneous tissue that is most prevalent in West African
Interferon-gamma is a crucial activator of early host immune defense against <em>Mycobacterium ulcerans</em> infection in mice (Publications)
Buruli ulcer (BU), caused by infection with Mycobacterium ulcerans, is a chronic necrotizing human skin disease associated with the production of the cytotoxic macrolide exotoxin mycolactone. Despite
Evaluation of <em>in vitro</em> antiprotozoal activity of <em>Ajuga laxmannii </em>and its secondary metabolites (Publications)
Context Some Ajuga L. (Lamiaceae) species are traditionally used for the treatment of malaria, as well as fever, which is a common symptom of many parasitic diseases. Objective In the continuation of
Annual and seasonal spatial models for nitrogen oxides in Tehran, Iran (Publications)
Very few land use regression (LUR) models have been developed for megacities in low- and middle-income countries, but such models are needed to facilitate epidemiologic research on air pollution. We d
Community knowledge, perceptions, and practices associated with urogenital schistosomiasis among school-aged children in Zanzibar, United Republic of... (Publications)
BACKGROUND: On the Zanzibar islands, United Republic of Tanzania, elimination of urogenital schistosomiasis is strived for in the coming years. This qualitative study aimed to better understand commun
Correlates and outcomes of posttransplant smoking in solid organ transplant recipients: a systematic literature review and meta-analysis (Publications)
BACKGROUND: Despite smoking being an absolute or relative contraindication for transplantation, about 11-40% of all patients continue or resume smoking posttransplant. This systematic review with meta
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, wher
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy (Publications)
The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmod
Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved <em>Plasmodium falciparum</em>... (Publications)
Controlled human malaria infection (CHMI) by mosquito bite has been used to assess new anti-malaria interventions in > 1,500 volunteers since development of methods for infecting mosquitoes by feeding
Quality of life is associated with physical activity and fitness in cystic fibrosis (Publications)
BACKGROUND: Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL mea