Polyclonal B-cell activation and autoantibody formation during the course of mosquito-transmitted <em>Plasmodium berghei</em> infection in mice (Publications)
The time course of polyclonal B cell activation, as measured by titers of antibodies to DNP, FITC, and haemocyanin, as well as the time course of autoantibody formation, was followed in mice infected
The health impacts of climate change and variability in developing countries (Publications)
Health is a focus reflecting the combined impacts of climate change on the physical environment, ecosystems, the economic environment and society. Long-term changes in the world's climate may affect m
Challenges in routine implementation and quality control of rapid diagnostic tests for malaria: Rufiji District, Tanzania (Publications)
Rapid diagnostic tests (RDTs) represent an alternative to microscopy for malaria diagnosis and have shown high sensitivity and specificity in a variety of study settings. Current World Health Organiza
Anthranoid compounds with antiprotozoal activity from <em>Vismia orientalis</em> (Publications)
A phytochemical investigation of the 80% ethanolic extract of stem bark of Vismia orientalis Engl. (Guttiferae or Clusiaceae), a plant used in traditional medicine in Tanzania, resulted in the isolati
Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Does resistance to pyrazinamide accurately indicate the presence of <em>Mycobacterium bovis</em>? (Publications)
Mycobacterium bovis is best identified by screening those isolates of the Mycobacterium tuberculosis complex that have any pyrazinamide (PZA) resistance, using a confirmatory test such as spoligotypin
Progression to active tuberculosis, but not transmission, varies by <em>Mycobacterium tuberculosis</em> lineage in The Gambia (Publications)
BACKGROUND: There is considerable variability in the outcome of Mycobacterium tuberculosis infection. We hypothesized that Mycobacterium africanum was less likely than M. tuberculosis to transmit and