Structure-activity relationship study of sesquiterpene lactones and their semi-synthetic amino derivatives as potential antitrypanosomal products (Publications)
Sesquiterpene lactones (STLs) are natural products that have potent antitrypanosomal activity in vitro and, in the case of cynaropicrin, also reduce parasitemia in the murine model of trypanosomiasis.
Water-related parasitic diseases in China (Publications)
Water-related parasitic diseases are directly dependent on water bodies for their spread or as a habitat for indispensable intermediate or final hosts. Along with socioeconomic development and improve
Antiprotozoal activity of <em>Buxus sempervirens</em> and activity-guided isolation of <em>O</em>-tigloylcyclovirobuxeine-B as the main constituent... (Publications)
Buxus sempervirens L. (European Box, Buxaceae) has been used in ethnomedicine to treat malaria. In the course of our screening of plant extracts for antiprotozoal activity, a CH2Cl2 extract from leave
Revising the WHO verbal autopsy instrument to facilitate routine cause-of-death monitoring (Publications)
Objective : Verbal autopsy (VA) is a systematic approach for determining causes of death (CoD) in populations without routine medical certification. It has mainly been used in research contexts and in
Malaria mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites (Publications)
BACKGROUND: Malaria continues to be a major cause of infectious disease mortality in tropical regions. However, deaths from malaria are most often not individually documented, and as a result overall
HIV/AIDS-related mortality in Africa and Asia: evidence from INDEPTH health and demographic surveillance system sites (Publications)
BACKGROUND: As the HIV/AIDS pandemic has evolved over recent decades, Africa has been the most affected region, even though a large proportion of HIV/AIDS deaths have not been documented at the indivi
Air pollution and mortality in seven million adults: the Dutch Environmental Longitudinal Study (DUELS) (Publications)
BACKGROUND: Long-term exposure to air pollution has been associated with mortality in urban cohort studies. Few studies have investigated this association in large scale population registries, includi
Cultural epidemiology of pandemic influenza in urban and rural Pune, India: a cross-sectional, mixed-methods study (Publications)
OBJECTIVE: To identify and compare sociocultural features of pandemic influenza with reference to illness-related experience, meaning and behaviour in urban and rural areas of India. DESIGN: Cross-sec
Emergence of a new epidemic <em>Neisseria meningitidis</em> serogroup A clone in the African meningitis belt: high-resolution picture of genomic... (Publications)
In the African "meningitis belt," outbreaks of meningococcal meningitis occur in cycles, representing a model for the role of host-pathogen interactions in epidemic processes. The periodicity of the e
Global epidemiology of yaws: a systematic review (Publications)
BACKGROUND: To achieve yaws eradication, the use of the new WHO strategy of initial mass treatment with azithromycin and surveillance twice a year needs to be extended everywhere the disease occurs. H