Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti
<em>Plasmodium</em> gametocytes display homing and vascular transmigration in the host bone marrow (Publications)
Transmission of Plasmodium parasites to the mosquito requires the formation and development of gametocytes. Studies in infected humans have shown that only the most mature forms of Plasmodium falcipar
The development and evaluation of a self-marking unit to estimate malaria vector survival and dispersal distance (Publications)
BACKGROUND: A clear understanding of mosquito biology is fundamental to the control efforts of mosquito-borne diseases such as malaria. Mosquito mark-release-recapture (MMRR) experiments are a popular
A novel lineage of ceftriaxone-resistant <em>Salmonella </em>Typhi from India that is closely related to XDR <em>S</em>. Typhi found in Pakistan (Publications)
Two MDR Salmonella Typhi isolates from India were found by whole genome sequencing to be closely related to the 2016 XDR S. Typhi outbreak strain from Pakistan. The Indian isolates have no chromosomal
Morbidity associated with <em>Schistosoma mekongi </em>and concurrent helminth infection in Lao People's Democratic Republic (Publications)
In 2006, some 7 years after the halt of a multi-year schistosomiasis control programme, a study was conducted in the southern part of Lao People's Democratic Republic to determine the morbidity associ
Patients with severe schistosomiasis mekongi morbidity in southern Lao People's Democratic Republic demonstrating ongoing transmission (Publications)
Chronic infection with Schistosoma mekongi may result in severe hepatosplenic morbidity. S. mekongi control programs aimed to prevent morbidity and mortality associated with infection. We report on ei
Antimalarial <em>N</em>1,<em>N</em>3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships (Publications)
Here we report the nanomolar potencies of N (1),N (3)-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of
Associations of various nighttime noise exposure indicators with objective sleep efficiency and self-reported sleep quality: a field study (Publications)
It is unclear which noise exposure time window and noise characteristics during nighttime are most detrimental for sleep quality in real-life settings. We conducted a field study with 105 volunteers w
Guidance for studies evaluating the accuracy of tuberculosis triage tests (Publications)
Approximately 3.6 million cases of active tuberculosis (TB) go potentially undiagnosed annually, partly due to limited access to confirmatory diagnostic tests, such as molecular assays or mycobacteria