Molecular and culture-based diagnosis of <em>Clostridium difficile</em> isolates from Côte d'Ivoire after prolonged storage at disrupted cold chain... (Publications)
BACKGROUND: Although Clostridium difficile is a major cause of diarrhoea, its epidemiology in tropical settings is poorly understood. Strain characterisation requires work-up in specialised laboratori
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-ba
Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children (Publications)
OBJECTIVES: Interferon-? inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults. This study aims to evaluate the potential of IP-10 di
Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes (Publications)
Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
There is an urgent need for the development of new antimalarial compounds. As a result of a phenotypic screen, several compounds with potent activity against the parasite Plasmodium falciparum were id
A research agenda to underpin malaria eradication (Publications)
The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scalin
Spatial and temporal dynamics of malaria transmission in rural western Kenya (Publications)
ABSTRACT: BACKGROUND: Understanding the impact of reducing Plasmodium falciparum malaria transmission requires estimates of the relationship between health outcomes and exposure to infectious mosquito
Household costs of illness during different phases of tuberculosis treatment in Central Asia: a patient survey in Tajikistan (Publications)
BACKGROUND: Illness-related costs incurred by patients constitute a severe economic burden for households especially in low-income countries. High household costs of illness lead to impoverishment; th