Frontiers of parasitology research in the People's Republic of China: infection, diagnosis, protection and surveillance (Publications)
ABSTRACT: Control and eventual elimination of human parasitic diseases in the People's Republic of China (P.R. China) requires novel approaches, particularly in the areas of diagnostics, mathematical
Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever (Publications)
BACKGROUND TO THE DEBATE: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub
On the origin of <em>Mycobacterium ulcerans</em>, the causative agent of Buruli ulcer (Publications)
ABSTRACT: BACKGROUND: Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closelyrelated to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to prod
Implementing new health interventions in developing countries: why do we lose a decade or more? (Publications)
BACKGROUND: It is unclear how long it takes for health interventions to transition from research and development (R&D) to being used against diseases prevalent in resource-poor countries. We undertook
Design, implementation and evaluation of a national campaign to distribute nine million free LLINs to children under five years of age in Tanzania (Publications)
ABSTRACT: BACKGROUND: After a national voucher scheme in 2004 provided pregnant women and infants with highly subsidized insecticide-treated nets (ITNs), use among children under five years (U5s) in m
Domestic dog demographic structure and dynamics relevant to rabies control planning in urban areas in Africa: the case of Iringa, Tanzania (Publications)
BACKGROUND: Mass vaccinations of domestic dogs have been shown to effectively control canine rabies and hence human exposure to rabies. Knowledge of dog population demography is essential for planning
Efficacy study of novel diamidine compounds in a <em>Trypanosoma evansi</em> goat model (Publications)
Three diamidines (DB 75, DB 867 and DB 1192) were selected and their ability to cure T. evansi experimentally infected goats was investigated. A toxicity assessment and pharmacokinetic analysis of the
A randomized placebo-controlled phase a malaria vaccine trial of two virosome-formulated synthetic peptides in healthy adult volunteers (Publications)
BACKGROUND AND OBJECTIVES: Influenza virosomes represent an innovative human-compatible antigen delivery system that has already proven its suitability for subunit vaccine design. The aim of the study