Advancing detection and response capacities for emerging and re-emerging pathogens in Africa (Publications)
Recurrent disease outbreaks caused by a range of emerging and resurging pathogens over the past decade reveal major gaps in public health preparedness, detection, and response systems in Africa. Under
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting o
Evaluation of nanopore sequencing for <em>Mycobacterium tuberculosis </em>drug susceptibility testing and outbreak investigation: a genomic analysis (Publications)
BACKGROUND: Mycobacterium tuberculosis whole-genome sequencing (WGS) has been widely used for genotypic drug susceptibility testing (DST) and outbreak investigation. For both applications, Illumina te
Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and... (Publications)
BACKGROUND: Rectal artesunate, an efficacious pre-referral treatment for severe malaria in children, was deployed at scale in Uganda, Nigeria, and DR Congo. In addition to distributing rectal artesuna
Urban onsite sanitation upgrades and synanthropic flies in Maputo, Mozambique: effects on enteric pathogen infection risks (Publications)
Synanthropic filth flies transport enteric pathogens from feces to food, which upon consumption poses an infection risk. We evaluated the effect of an onsite sanitation intervention horizontal line in
Co-infection of the four major <em>Plasmodium </em>species: effects on densities and gametocyte carriage (Publications)
BACKGROUND: Co-infection of the four major species of human malaria parasite Plasmodium falciparum (Pf), P. vivax (Pv), P. malariae (Pm), and P. ovale sp. (Po) is regularly observed, but there is limi
Modulation of host-parasite interactions with small molecules targeting <em>Schistosoma mansoni </em>microRNAs (Publications)
Parasites use different strategies of communication with their hosts. One communication channel that has been studied in recent years is the use of vesicle microRNAs to influence the host immune syste
The evolving SARS-CoV-2 epidemic in Africa: insights from rapidly expanding genomic surveillance (Publications)
Investment in SARS-CoV-2 sequencing in Africa over the past year has led to a major increase in the number of sequences generated, now exceeding 100,000 genomes, used to track the pandemic on the cont
Acceptability measures of water, sanitation and hygiene interventions in low- and middle-income countries, a systematic review (Publications)
BACKGROUND: Inadequate access to water, sanitation, and hygiene (WASH) is an environmental risk factor for poor health outcomes globally, particularly for children in low- and middle-income countries
COVID-19 vaccine booster strategies in light of emerging viral variants: frequency, timing, and target groups (Publications)
BACKGROUND: Vaccinations have reduced severe burden of COVID-19 and allowed for lifting of non-pharmaceutical interventions. However, with immunity waning alongside emergence of more transmissible var