Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selecti
Efficacy and safety of CGP 56697 (artemether and benflumetol) compared with chloroquine to treat acute falciparum malaria in Tanzanian children aged... (Publications)
A randomized, open trial involving 260 Tanzanian children, aged 1-5 years, with acute Plasmodium falciparum malaria was conducted to evaluate the efficacy of the combination antimalarial CGP 56697 (ar
A prospective study of <em>Plasmodium falciparum</em> multiplicity of infection and morbidity in Tanzanian children (Publications)
Several studies suggest that in individuals with substantial previous exposure to malaria, co-infection with multiple clones of Plasmodium falciparum can protect against subsequent clinical malaria at
Somatization revisited: diagnosis and perceived causes of common mental disorders (Publications)
The assessment of somatoform disorders is complicated by persistent theoretical and practical questions of classification and assessment. Critical rethinking of professional concepts of somatization s
Physical activity, bodyweight, health and fear of negative evaluation in primary school children (Publications)
Fear of negative evaluation (FNE) is regarded as being the core feature of social anxiety. The present study examined how FNE is associated with physical activity (PA), body mass index (BMI) and perce
Development and interactions of <em>Trypanosoma rangeli</em> in and with the reduviid bug <em>Rhodnius prolixus</em> (Publications)
Two strains of Trypanosoma rangeli and three strains of Rhodnius prolixus were used in various combinations to transmit the trypanosomes via the reduviid bug. A persisting infection in the midgut lume
Regulation of ABCB1/PGP1-catalysed auxin transport by linker phosphorylation (Publications)
Polar transport of the plant hormone auxin is controlled by PIN- and ABCB/PGP-efflux catalysts. PIN polarity is regulated by the AGC protein kinase, PINOID (PID), while ABCB activity was shown to be d