Development and validation of the Kilifi epilepsy beliefs and attitude scale (Publications)
Epilepsy remains misunderstood, particularly in resource poor countries (RPC). We developed and validated a tool to assess beliefs and attitudes about epilepsy among people with epilepsy (PWE) in Kili
Synthesis and in vitro antimalarial testing of neocryptolepines: SAR study for improved activity by introduction and modifications of side chains at... (Publications)
In order to obtain a high antimalarial activity with neocryptolepine derivatives, modifying and changing the side chains at the C11 position with varying the substituents of an electron-withdrawing or
Comparative detection of trypanosomal DNA by loop mediated isotherma amplification and PCR from FTA cards spotted with patient blood (Publications)
We analyzed DNA eluted from FTA (Flinders Technology Associates) cards spotted with blood from Human African Trypanosomiasis (HAT) patients admitted at Lwala Hospital, Eastern Uganda, and Kaliua Healt
Contribution of physical education to overall physical activity (Publications)
For many children, physical activity (PA) during physical education (PE) lessons provides an important opportunity for being physically active. Although PA during PE has been shown to be low, little i
Synthesis and antimalarial and antituberculosis activities of a series of natural and unnatural 4-methoxy-6-styryl-pyran-2-ones, dihydro analogues and... (Publications)
Previous studies have identified the 3,6-dialkyl-4-hydroxy-pyran-2-one marine microbial metabolites pseudopyronines A and B to be modest growth inhibitors of Mycobacterium tuberculosis and a range of
Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of <em>Plasmodium falciparum</em> dUTP... (Publications)
The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibitio
Quantification of self pollution from two diesel school buses using three independent methods (Publications)
We monitored two Seattle school buses to quantify the buses' self pollution using the dual tracers (DT), lead vehicle (LV), and chemical mass balance (CMB) methods. Each bus drove along a residential
Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites (Publications)
Non-functional analogs of the cofactors ATP and NAD are putative inhibitors of ATP- or NAD-dependant enzymes. Since pathogenic protozoa rely heavily on the salvage of purine nucleosides from the blood