Nifurtimox-eflornithine combination therapy for second-stage African <em>Trypanosoma brucei gambiense</em> trypanosomiasis: a multicentre, randomised,... (Publications)
BACKGROUND: Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for patients with second-stage disease are toxic
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines (Publications)
The synthesis and full 3D structural characterization of nine new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinoline derivatives are reported. These belong to a library whose rationale for the des
Human antibodies to recombinant protein constructs of <em>Plasmodium falciparum</em> Apical Membrane Antigen 1 (AMA1) and their associations with... (Publications)
Serum antibodies from 1071 people in two Kenyan villages were assayed using eight different recombinant Apical Membrane Antigen 1 (AMA1) protein constructs to investigate their role in naturally acqui
Long-term outcome in elderly patients with chronic angina managed invasively versus by optimized medical therapy: four-year follow-up of the... (Publications)
BACKGROUND: There are no prospective trial data on long-term outcomes in 80-year-old patients with chronic angina with regard to antiischemic therapy. METHODS AND RESULTS: To assess long-term survival
Size fractionate particulate matter, vehicle traffic, and case-specific daily mortality in Barcelona, Spain (Publications)
Recent epidemiological research suggests that short-term effects of particle matter (PM) in urban areas may preferentially be driven by fine fractions. Questions remain concerning the adversehealth ef
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin (Publications)
In two steps from dihydroartemisinin, a small array of 16 semisynthetic C-10 pyrrole Mannich artemisinin derivatives (7a-p) have been prepared in moderate to excellent yield. In vitro analysis against
Does radical cure of asymptomatic <em>Plasmodium falciparum</em> place adults in endemic areas at increased risk of recurrent symptomatic malaria? (Publications)
A cohort of 197 adults in Kassena-Nankana District (northern Ghana) was radically cured of malaria parasites to study subsequent incidence of malaria infection. During the following 20 weeks of the ma