Cynaropicrin: the first plant natural product with <em>in vivo</em> activity against <em>Trypanosoma brucei</em> (Publications)
A screen of 1800 plant and fungal extracts with subsequent HPLC-based activity profiling was done to identify new antiprotozoal leads from nature. This led to the identification of cynaropicrin (1) fr
Tegumental changes in adult <em>Schistosoma mansoni</em> harboured in mice treated with praziquantel enantiomers (Publications)
Praziquantel administered to the host causes damage to the tegument of Schistosoma mansoni. In this study, the effects of racemic praziquantel (Pra) and its enantiomers, levo-praziquantel (L-Pra) and
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL) (Publications)
Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania
Effect of strategic gastrointestinal nematode control on growth of N'Dama cattle in Gambia (Publications)
From October 1989 to December 1994, a longitudinal study on the control of gastrointestinal nematodes was done on 1000 N'Dama cattle in 20 private herds in Gambia. Each herd was divided into two group
Prolonged suppression of trichostrongyle egg output of N'Dama cattle by a single larvicidal treatment (Publications)
Gambian village cattle herds were treated with a single dose of ivermectine (Ivomec, MSD-AGVET Inc. 1 ml/50 kg body weight) during the dry season. This treatment suppressed the trichostrongyle egg ris
Evaluation of decontamination methods and growth media for primary isolation of <em>Mycobacterium ulcerans</em> from surgical specimens (Publications)
We evaluated four decontamination methods and one nondecontamination procedure in combination with four egg-based media for the primary isolation of Mycobacterium ulcerans from tissue specimens. With
The 1992-1999 World Bank Schistosomiasis Research Initiative in China: outcome and perspectives (Publications)
Ongoing efforts over the last 50 years, aiming at the elimination of schistosomiasis in the People's Republic of China, have been spectaculary successful in reducing the prevalence and intensity of th