Assessment of factors influencing retention in the Philippine National Rural Physician Deployment Program (Publications)
BACKGROUND: The 'Doctors to the Barrios' (DTTB) Program was launched in 1993 in response to the shortage of doctors in remote communities in the Philippines. While the Program has attracted physicians
A clinical prediction score in addition to WHO criteria for anti-retroviral treatment failure in resource-limited settings: experience from Lesotho (Publications)
OBJECTIVE: To assess the positive predictive value (PPV) of a clinical score for viral failure among patients fulfilling the WHO-criteria for anti-retroviral treatment (ART) failure in rural Lesotho.
The past and future of tuberculosis research (Publications)
Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, di
How many mosquito nets are needed to achieve universal coverage? Recommendations for the quantification and allocation of long-lasting insecticidal... (Publications)
BACKGROUND: Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. Howeve
The influence of host and bacterial genotype on the development of disseminated disease with <em>Mycobacterium tuberculosis</em> (Publications)
The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causi
Sterilising effects of pyriproxyfen on <em>Anopheles arabiensis</em> and its potential use in malaria control (Publications)
BACKGROUND: Insecticide resistance poses a major threat to current vector control campaigns. Insecticides with novel modes of action are therefore in high demand. Pyriproxyfen (PPF), a conventional mo
The genetic architecture of type 2 diabetes (Publications)
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association st
Discovery of antischistosomal drug leads based on tetraazamacrocyclic derivatives and their metal complexes (Publications)
Praziquantel (PZQ) is the only available drug to treat schistosomiasis, and since its large scale use might be associated with the onset of resistance, new antischistosomal drugs should be developed.
School distribution as keep-up strategy to maintain universal coverage of long-lasting insecticidal nets: implementation and results of a program in... (Publications)
Tanzania successfully scaled up coverage of long-lasting insecticidal nets (LLINs) through mass campaigns. To sustain these gains, a school-based approach was piloted in the country's Southern Zone st