Antitrypanosomal structure-activity-relationship study of synthetic cynaropicrin derivatives (Publications)
Cynaropicrin is a guaianolide sesquiterpene lactone with a 5-7-5 tricyclic skeleton, four exo-olefins, and two hydroxyl groups. Recently, it was found that the compound is a potent in vitro and in viv
Predictive risk mapping of schistosomiasis in Brazil using Bayesian geostatistical models (Publications)
Schistosomiasis is one of the most common parasitic diseases in tropical and subtropical areas, including Brazil. A national control programme has been instigated in Brazil in the mid-1970s and proved
Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt (Publications)
For over 100 years, large epidemics of meningococcal meningitis have occurred every few years in areas of the African Sahel and sub-Sahel known as the African meningitis belt. Until recently, the main
A computational framework folr integration of lipidomics data into metabolic pathways (Publications)
Lipids are important compounds for human physiology and as renewable resources for fuels and chemicals. In lipid research, there is a big gap between the currently available pathway-level representati
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo (Publications)
Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of
Crucial issues in think aloud techniques for cross cultural studies (Publications)
Implementing user-centered design (UCD) principles and conducting usability testing is especially critical in projects where developers do not originate from the deployed environment. However, traditi