Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against <em>Schistosoma mansoni </em>and <em>Schistosoma... (Publications)
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting contr
School children's intestinal parasite and nutritional status 1 year after complementary school garden, nutrition, water, sanitation, and hygiene... (Publications)
The potential health benefits of combined agricultural, nutrition, water, sanitation, and hygiene (WASH) interventions are poorly understood. We aimed to determine whether complementary school garden,
Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the <em>Schistosoma mansoni</em> mouse model (Publications)
After more than 40 years of use, Praziquantel (PZQ) still remains the drug of choice for the treatment of intestinal and urogenital schistosomiasis. Its anti-parasitic activity resides primarily in th
A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape... (Publications)
BACKGROUND: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with
Nasopharyngeal pneumococcal density is associated with viral activity but not with use of improved stoves among young Andean children (Publications)
BACKGROUND: Indoor smoke exposure is common in developing countries and may influence nasopharyngeal (NP) pneumococcal colonization density and risk of acute respiratory illness. We compared colonizat
The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines (Publications)
A limited number of novel 3-nitrotriazole- and 2-nitroimidazole-linked quinolines and quinazolines were synthesized and screened for in vitro antitrypanosomal and antitubercular activities as well as
Antimalarial inhibitors targeting serine hydroxymethyltransferase (SHMT) with <em>in vivo</em> efficacy and analysis of their binding mode based on... (Publications)
Target-based approaches toward new antimalarial treatments are highly valuable to prevent resistance development. We report several series of pyrazolopyran-based inhibitors targeting the enzyme serine