Protein degradation in mitochondria (Publications)
The biogenesis of mitochondria and the maintenance of mitochondrial functions depends on an autonomous proteolytic system in the organelle which is highly conserved throughout evolution. Components of
Evolution of two distinct phylogenetic lineages of the emerging human pathogen <em>Mycobacterium ulcerans</em> (Publications)
ABSTRACT: BACKGROUND: Comparative genomics has greatly improved our understanding of the evolution of pathogenic mycobacteria such as Mycobacterium tuberculosis. Here we have used data from a genome m
Research capacity strengthening in low and middle income countries - an evaluation of the WHO/TDR career development fellowship programme (Publications)
Between August 2012 and April 2013 the Career Development Fellowship programme of the Special Programme for Research and Training in Tropical Diseases (World Health Organization) underwent an external
Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to <em>Mycobacterium... (Publications)
Mycolactone is an immunosuppressive cytotoxin responsible for the clinical manifestation of Buruli ulcer in humans. It was believed to be confined to its etiologic agent, Mycobacterium ulcerans. Howev
Independent loss of immunogenic proteins in <em>Mycobacterium ulcerans</em> suggests immune evasion (Publications)
The highly immunogenic mycobacterial proteins ESAT-6, CFP-10, and HspX represent potential target antigens for the development of subunit vaccines and immunodiagnostic tests. Recently, the complete ge
Simplifying paediatric immunization with a fully liquid DTP-HepB-Hib combination vaccine: evidence from a comparative time-motion study in India (Publications)
An observational time-motion study investigated logistic, programmatic and safety-related advantages and limits in the delivery of a fully liquid DTP-HepB-Hib combination vaccine versus a lyophilized