Using yeast synthetic lethality to inform drug combination for malaria (Publications)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of t
Population genomics of <em>Francisella tularensis </em>subsp.<em> holarctica</em> and its implication on the eco-epidemiology of tularemia in... (Publications)
Whole genome sequencing (WGS) methods provide new possibilities in the field of molecular epidemiology. This is particularly true for monomorphic organisms where the discriminatory power of traditiona
Hyperglycaemia is inversely correlated with live <em>M. bovis</em> BCG-specific CD4+ T cell responses in Tanzanian adults with latent or active... (Publications)
INTRODUCTION: The rising prevalence of Diabetes mellitus (DM) in high TB-endemic countries may adversely affect sustainability of TB control since DM constitutes a risk factor for development of activ
Talking about sex in pregnancy: reflections from the field in urban South Africa (Publications)
Qualitative research with close engagement in the field allows researchers and participants to build relationships and establish trust, enabling researchers to collect meaningful and sensitive informa
<em>In vitro </em>and<em> in vivo</em> studies of the trypanocidal effect of novel quinolines (Publications)
Therapies for human African trypanosomiasis and Chagas disease, caused by Trypanosoma brucei and Trypanosoma cruzi, respectively, are limited, providing minimal therapeutic options for the millions of
Human migration and the spread of malaria parasites to the New World (Publications)
We examined the mitogenomes of a large global collection of human malaria parasites to explore how and when Plasmodium falciparum and P. vivax entered the Americas. We found evidence of a significant
<em>Plasmodium vivax </em>molecular diagnostics in community surveys: pitfalls and solutions (Publications)
A distinctive feature of Plasmodium vivax infections is the overall low parasite density in peripheral blood. Thus, identifying asymptomatic infected individuals in endemic communities requires diagno