Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis (Publications)
Asthma and chronic obstructive pulmonary disease (COPD) are thought to share a genetic background ("Dutch hypothesis"). We investigated whether asthma and COPD have common underlying genetic factors,
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? (Publications)
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA
Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland (Publications)
Given the shrinking spatial contrasts in outdoor air pollution in Switzerland and the trends toward tightly insulated buildings, the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in
Early detection of subjects at risk for vascular remodelling - results from the Swiss population-based study SAPALDIA (Publications)
QUESTIONS UNDER STUDY: As the burden of cardiovascular disease (CVD) increases globally, its prevention and risk assessment becomes ever more important. We thus investigated the longitudinal associati
Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline (Publications)
OBJECTIVES: We evaluated interactions between SERPINA1 PiMZ genotype, associated with intermediate alpha1-antitrysin deficiency, with outdoor particulate matter
Sleep fragmentation and sleep-disordered breathing in individuals living close to main roads: results from a population-based study (Publications)
BACKGROUND: Nighttime traffic noise is associated with sleep disturbances, but sleep fragmentation and sleep-disordered breathing (SDB) have not been demonstrated in individuals living near busy roads
Years of life lost and morbidity cases attributable to transportation noise and air pollution: a comparative health risk assessment for Switzerland in... (Publications)
BACKGROUND: There is growing evidence that chronic exposure to transportation related noise and air pollution affects human health. However, health burden to a country of these two pollutants have bee
Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort (Publications)
OBJECTIVE: Air pollution and obesity are hypothesized to contribute to accelerated lung function decline with age through their inflammatory properties. We investigated whether the previously reported
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis (Publications)
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, c