Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against <em>Schistosoma mansoni</em> (Publications)
BACKGROUND: The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, whi
Prevalence and clinical significance of respiratory viruses and bacteria detected in tuberculosis patients compared to household contact controls in... (Publications)
OBJECTIVES: To describe the prevalence of respiratory pathogens in tuberculosis (TB) patients and in their household contact controls, and to determine the clinical significance of respiratory pathoge
Combined approach of backbone amide linking and on-resin n-methylation for the synthesis of bioactive and metabolically stable peptides (Publications)
Rhabdopeptides are a large class of nonribosomal peptides from the bacteria Xenorhabdus and Photorhabdus with low micromolar activity against different protozoa, which are the causative agents of seve
Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold (Publications)
With the discovery that serine hydroxymethyltransferase (SHMT) is a druggable target for antimalarials, the aim of this study was to design novel inhibitors of this key enzyme in the folate biosynthes
Anemia in tuberculosis cases and household controls from Tanzania: contribution of disease, coinfections, and the role of hepcidin (Publications)
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat out
Rickettsial illnesses as important causes of febrile illness in Chittagong, Bangladesh (Publications)
We conducted a yearlong prospective study of febrile patients admitted to a tertiary referral hospital in Chittagong, Bangladesh, to assess the proportion of patients with rickettsial illnesses and id