Epithelial innate immunity. A novel antimicrobial peptide with antiparasitic activity in the blood-sucking insect<em> Stomoxys calcitrans</em> (Publications)
The gut epithelium is an essential interface in insects that transmit parasites. We investigated the role that local innate immunity might have on vector competence, taking Stomoxys calcitrans as a mo
The National Schistosomiasis Control Programme in Mali: objectives, organization, results (Publications)
Schistosomiasis control started regionally, in the Bandiagara district, and as a component of a dam-building project in 1978. In 1982 a national programme was created. Control was divided into three p
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from <em>Ancistrocladus tanzaniensis</em> (Publications)
Three new naphthylisoquinoline alkaloids, the 7,3'-coupled ancistrotanzanine C (6), the 5,1'-coupled O-methylancistrocladinine (7), and the likewise 5,1'-coupled O,N-dimethylancistrocladine (8, previo
Synthesis and antiprotozoal activities of simplified analogs of naphthylisoquinoline alkaloids (Publications)
The naphthylisoquinoline alkaloids (NIQs) represent a class of natural products with manifold activities against various tropical diseases. They are isolated from rare and difficult-to-cultivate tropi
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines (Publications)
The naphthylisoquinoline (NIQ) alkaloids from tropical Ancistrocladaceae and Dioncophyllaceae plants show high antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strain
Six naphthylisoquinoline alkaloids and a related benzopyranone from a Congolese <em>Ancistrocladus</em> species related to <em>Ancistrocladus... (Publications)
From the roots of a recently discovered Ancistrocladus taxon, with close affinities to Ancistrocladus congolensis regarding molecular ITS sequence data, six naphthylisoquinoline alkaloids, 5'-O-demeth
Dioncophylline E from Dioncophyllum thollonii, the first 7,3'-coupled dioncophyllaceous naphthylisoquinoline alkaloid (Publications)
The isolation and structural elucidation of dioncophylline E, a novel naphthylisoquinoline alkaloid from the rare West African liana Dioncophyllum thollonii, is described. The alkaloid displays an unu
Antitrypanosomal cycloartane glycosides from Astragalus baibutensis (Publications)
Baibutoside (5), a new cycloartane-type triterpene glycoside, has been isolated from the roots of Astragalus baibutensis along with four known glycosides, acetylastragaloside I (1), and astragalosides