Anti-inflammatory and antimalarial meroterpenoids from the New Zealand ascidian <em>Aplidium scabellum</em> (Publications)
Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1)
Developmental impairments following severe falciparum malaria in children (Publications)
OBJECTIVE: Neurological deficits are reported in children after cerebral malaria (CM) but little is known about the prevalence and characteristics of persisting neurocognitive consequences. The preval
Field evaluation of a recombinant glutathione S-transferase-based pyrethroid quantification assay (Publications)
A recombinant glutathione S-transferase (GST)-based pyrethroid quantification assay was field-tested in Ifakara, Tanzania. Initial laboratory tests suggested that all reagents used in the assay should
Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
Trypanothione reductase (TR) is a flavoenzyme unique to trypanosomatid parasites and a target for lead discovery programs. Various inhibitor scaffolds have emerged in the past, exhibiting moderate aff
Pan-dengue virus detection by PCR for travelers returning from the tropics (Publications)
We performed dengue virus (DENV) serology and quantitative real-time pan-DENV reverse transcription-PCR (RT-PCR) on 186 sera of 171 patients returning from the tropics. DENV loads significantly decrea
<em>Fasciola hepatica</em>: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats (Publications)
We compared the sedimentation and FLOTAC techniques for the detection and quantification of Fasciola hepatica eggs in faecal samples obtained from 120 experimentally-infected rats before intervention,