Bacterial genome-wide association study of hyper-virulent pneumococcal serotype 1 identifies genetic variation associated with neurotropism (Publications)
Hyper-virulent Streptococcus pneumoniae serotype 1 strains are endemic in Sub-Saharan Africa and frequently cause lethal meningitis outbreaks. It remains unknown whether genetic variation in serotype
Core components and impact of nurse-led integrated care models for home-dwelling older people: a systematic review and meta-analysis (Publications)
BACKGROUND: Integrated care models are highly recommended to overcome care fragmentation in the multimorbid older population. Nurses are potentially ideally situated to fulfil the role as care coordin
Activation, structure, biosynthesis and bioactivity of glidobactin-like proteasome inhibitors from <em>Photorhabdus laumondii</em> (Publications)
The glidobactin-like natural products (GLNPs) glidobactin A and cepafungin I have been reported to be potent proteasome inhibitors and are regarded as promising candidates for anti-cancer drug develop
Unusual derivatives from <em>Hypericum scabrum</em> (Publications)
Three new compounds (1-3) with unusual skeletons were isolated from the n-hexane extract of the air-dried aerial parts of Hypericum scabrum. Compound 1 represents the first example of an esterified po
Impact of social accountability monitoring on health facility performance: evidence from Tanzania (Publications)
Social accountability programs are increasingly used to improve the performance of public service providers in low-income settings. Despite their growing popularity, evidence on the effectiveness of s
Enhancing the understanding of resilience in health systems of low- and middle-income countries: a qualitative evidence synthesis (Publications)
Background A country’s health system faces pressure when hit by an unexpected shock, such as what we observe in the midst of the coronavirus disease 2019 (COVID-19) pandemic. The concept of resilience
Structure of trypanosome coat protein VSGsur and function in suramin resistance (Publications)
Suramin has been a primary early-stage treatment for African trypanosomiasis for nearly 100 yr. Recent studies revealed that trypanosome strains that express the variant surface glycoprotein (VSG) VSG
External exposome and all-cause mortality in European cohorts: the EXPANSE project (Publications)
Background: Many studies reported associations between long-term exposure to environmental factors and mortality; however, little is known on the combined effects of these factors and health. We aimed