New diagnostic tools in schistosomiasis (Publications)
Schistosomiasis is a water-based parasitic disease that affects over 250 million people. Control efforts have long been in vain, which is one reason why schistosomiasis is considered a neglected tropi
One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I (Publications)
OBJECTIVE: We aimed to prospectively derive and validate a novel 1h-algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for early rule-out and rule-in of acute myocardial infarction. METHODS
Clinical features for diagnosis of pneumonia in children younger than 5 years: a systematic review and meta-analysis (Publications)
BACKGROUND: Pneumonia is the biggest cause of deaths in young children in developing countries, but early diagnosis and intervention can effectively reduce mortality. We aimed to assess the diagnostic
Detection of <em>Mycobacterium tuberculosis</em> by EasyNAT diagnostic kit in sputum samples from Tanzania (Publications)
EasyNAT was evaluated for detection of tuberculosis in sputum smears of presumptive pulmonary TB patients in an African high TB and HIV setting. The sensitivity of EasyNAT was 66.7%, specificity and p
Impact de l'urbanisation sur l'indice plasmodique et les densités parasitaires chez les enfants de 0 à 5 ans dans la commune de Yopougon, Abidjan... (Publications)
From September 23-30, 2005, we conducted a cross-sectional study in six townships of Yopougon, a municipality of Abidjan. These townships were grouped in three levels of urbanization (village, precari
Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal (Publications)
OBJECTIVES: Praziquantel is the only drug available for the treatment of schistosomiasis and the state of the exhausted drug discovery pipeline is alarming. We restarted investigations on the abandone
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities (Publications)
Several of the enzymes related to the folate cycle are well-known for their role as clinically validated antimalarial targets. Nevertheless for serine hydroxymethyltransferase (SHMT), one of the key e
The WHO ultrasonography protocol for assessing morbidity due to <em>Schistosoma haematobium</em>: acceptance and evolution over 14 years: systematic... (Publications)
In 2000, the World Health Organization (WHO) published an ultrasound field protocol for assessing morbidity due to schistosomiasis. The present study aims to review the acceptance of the WHO protocol