Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on... (Publications)
Trypanothione reductase (TR) is a flavoenzyme unique to trypanosomatid parasites and a target for lead discovery programs. Various inhibitor scaffolds have emerged in the past, exhibiting moderate aff
Using <em>Drosophila melanogaster</em> to validate metabolism-based insecticide resistance from insect pests (Publications)
Identifying molecular mechanisms of insecticide resistance is important for preserving insecticide efficacy, developing new insecticides and implementing insect control. The metabolic detoxification o
Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm (Publications)
RATIONALE: The few prospective studies aimed at assessing the incidence of chronic obstructive pulmonary disease (COPD) in relation to the presence of chronic cough/phlegm have produced contrasting re
Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria... (Publications)
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance. Therefore, techniques are
Value of ultrasonography in investigating morbidity due to <em>Schistosoma haematobium</em> infection (Publications)
In an area where urinary schistosomiasis was endemic 349 patients were examined by ultrasonography. To evaluate the sensitivity and specificity of this technique, intravenous pyelography and cystoscop
Does <em>M. tuberculosis</em> genomic diversity explain disease diversity? (Publications)
The outcome of tuberculosis infection and disease is highly variable. This variation has been attributed primarily to host and environmental factors, but better understanding of the global genomic div
Association of FEV1 in asthmatic children with personal and microenvironmental exposure to airborne particulate matter (Publications)
Exposure to particulate matter (PM) air pollution has been shown to exacerbate children's asthma, but the exposure sources and temporal characteristics are still under study. Children's exposure to PM