Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-ba
Blood or urine IP-10 cannot discriminate between active tuberculosis and respiratory diseases different from tuberculosis in children (Publications)
OBJECTIVES: Interferon-? inducible protein 10 (IP-10), either in blood or in urine, has been proposed as a tuberculosis (TB) biomarker for adults. This study aims to evaluate the potential of IP-10 di
Synthesis and antiprotozoal activities of new 3-azabicyclo[3.2.2]nonanes (Publications)
Some antimalarial agents in use typically bear basic side chains as ligands. Such ligands were attached to the amino substituent of a bridgehead atom of already antiprotozoal active 3-azabicyclo[3.2.2
Malaria molecular epidemiology: lessons from the International Centers of Excellence for Malaria Research Network (Publications)
Molecular epidemiology leverages genetic information to study the risk factors that affect the frequency and distribution of malaria cases. This article describes molecular epidemiologic investigation
Burden of serious fungal infections in Tanzania (Publications)
The incidence and prevalence of fungal infections in Tanzania remains unknown. We assessed the annual burden in the general population and among populations at risk. Data were extracted from 2012 repo
A novel pyrazolopyridine with<em> in vivo</em> activity in <em>Plasmodium berghei</em>- and <em>Plasmodium falciparum</em>-infected mouse models from... (Publications)
Toward improving pharmacokinetics, in vivo efficacy, and selectivity over hERG, structure-activity relationship studies around the central core of antimalarial imidazopyridazines were conducted. This
A research agenda to underpin malaria eradication (Publications)
The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scalin
Spatial and temporal dynamics of malaria transmission in rural western Kenya (Publications)
ABSTRACT: BACKGROUND: Understanding the impact of reducing Plasmodium falciparum malaria transmission requires estimates of the relationship between health outcomes and exposure to infectious mosquito
Household costs of illness during different phases of tuberculosis treatment in Central Asia: a patient survey in Tajikistan (Publications)
BACKGROUND: Illness-related costs incurred by patients constitute a severe economic burden for households especially in low-income countries. High household costs of illness lead to impoverishment; th