International workshop on insecticide resistance in vectors of arboviruses, December 2016, Rio de Janeiro, Brazil (Publications)
Vector-borne diseases transmitted by insect vectors such as mosquitoes occur in over 100 countries and affect almost half of the world's population. Dengue is currently the most prevalent arboviral di
Occurrence of and risk factors for <em>Strongyloides stercoralis</em> infection in South-East Asia (Publications)
The soil-transmitted nematode, Strongyloides stercoralis is one of the most-neglected of all neglected tropical diseases. It is globally distributed, favouring the humid, wet climates of the tropics a
The macrolide toxin mycolactone promotes bim-dependent apoptosis in Buruli ulcer through inhibition of mTOR (Publications)
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, is central to the pathogenesis of the chronic necrotizing skin disease Buruli ulcer (BU). Here we show that mycolactone acts as
Modelling the health and economic impacts of the elimination of river blindness (onchocerciasis) in Africa (Publications)
BACKGROUND: Onchocerciasis (river blindness) is endemic mostly in remote and rural areas in sub-Saharan Africa. The treatment goal for onchocerciasis has shifted from control to elimination in Africa.
Tuberculosis treatment outcomes among HIV/TB-coinfected children in the International Epidemiology Databases to Evaluate AIDS (IeDEA) network (Publications)
INTRODUCTION: Management of tuberculosis (TB) is challenging in HIV/TB-coinfected children. The World Health Organization recommends nucleic acid amplification tests for TB diagnosis, a 4-drug regimen
Hit-to-lead optimization of a novel class of potent, broad-spectrum trypanosomacides (Publications)
The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently availa
TbIRK is a signature sequence free potassium channel from <em>Trypanosoma brucei</em> locating to acidocalcisomes (Publications)
Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter. Using a screening approach with ion chan
European Community Respiratory Health Survey II : final report of work package 6 : PM2.5 assessment in 21 European cities of ECRHS II (Publications)
The follow-up of a cohort of adults from 29 European centres of the former ECRHS I (1989-1992) will examine the long-term effects of exposure to ambient air pollution on the incidence, course, and pro
Cost description and comparative cost efficiency of post-exposure prophylaxis and canine mass vaccination against rabies in N'Djamena, Chad (Publications)
Rabies claims approximately 59,000 human lives annually and is a potential risk to 3.3 billion people in over 100 countries worldwide. Despite being fatal in almost 100% of cases, human rabies can be