Egg-laying and locomotory screens with <em>C. elegans </em>yield a nematode-selective small molecule stimulator of neurotransmitter release (Publications)
Nematode parasites of humans, livestock and crops dramatically impact human health and welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to anthelmintic drugs, and tr
Does global health governance walk the talk? Gender representation in World Health Assemblies, 1948-2021 (Publications)
BACKGROUND: While an estimated 70%-75% of the health workforce are women, this is not reflected in the leadership roles of most health organisations-including global decision-making bodies such as the
Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT) (Publications)
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a men
Deconstructing design thinking as a tool for the implementation of a population health initiative (Publications)
BACKGROUND: The translation of evidence-based practices and rapid uptake of innovations into global health practice is challenging. Design thinking is a consultative process involving multiple stakeho
Different classes of genomic inserts contribute to human antibody diversity (Publications)
Recombination of antibody genes in B cells can involve distant genomic loci and contribute a foreign antigen-binding element to form hybrid antibodies with broad reactivity for Plasmodium falciparum.
2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: <em>in vitro</em> and <em>in vivo </em>study (Publications)
Nitro-containing compounds are a well-known class of anti-infective agents, especially in the field of anti-parasitic drug discovery. HAT or sleeping sickness is a neglected tropical disease caused by
Europe-wide air pollution modeling from 2000 to 2019 using geographically weighted regression (Publications)
Previous European land-use regression (LUR) models assumed fixed linear relationships between air pollution concentrations and predictors such as traffic and land use. We evaluated whether including s
The source of individual heterogeneity shapes infectious disease outbreaks (Publications)
There is known heterogeneity between individuals in infectious disease transmission patterns. The source of this heterogeneity is thought to affect epidemiological dynamics but studies tend not to con
Simple clinical and laboratory predictors to improve empirical treatment strategies in areas of high scrub typhus and dengue endemicity, central... (Publications)
BACKGROUND: Dengue fever is highly endemic in Vietnam, but scrub typhus-although recognized as an endemic disease-remains underappreciated. These diseases together are likely to account for more than
Effectiveness of four different interventions against <em>Schistosoma haematobium</em> in a seasonal transmission setting of Côte d'Ivoire: a cluster... (Publications)
BACKGROUND: Annual mass drug administration (MDA) using praziquantel is the cornerstone of schistosomiasis morbidity control, but is not sufficient to interrupt transmission. We implemented a cluster-